Comparison of intracervical, intrauterine, and intratubal techniques for donor insemination.

Published

Journal Article

To compare the efficacy of intracervical insemination (ICI), intrauterine insemination (IUI), and a combination of intratubal and intrauterine insemination (ITI/IUI) for donor insemination.Prospective randomized clinical trial.The University of Michigan donor insemination program.Forty-one women undergoing donor insemination with cryopreserved sperm for either isolated male factor or male factor plus ovulatory dysfunction corrected by clomiphene citrate.Each patient was randomly assigned to receive each of the three insemination techniques in consecutive cycles until pregnancy occurred or the patient dropped from the study.Cycle fecundity rates were compared using the chi 2 test, and cumulative pregnancy rates (PRs) determined by life table analysis were compared using a log-rank test.Cycle fecundity rate was significantly higher for IUI (18.3%) than for ICI (3.9%) or ITI/IUI (7.3%). By life table analysis, the cumulative PR for IUI was significantly higher than for ICI, but the PR for ITI/IUI was not.For donor insemination with cryopreserved sperm, IUI increases cycle fecundity compared with ICI. The addition of ITI to IUI, however, interferes with the apparent beneficial effect of IUI alone.

Full Text

Duke Authors

Cited Authors

  • Hurd, WW; Randolph, JF; Ansbacher, R; Menge, AC; Ohl, DA; Brown, AN

Published Date

  • February 1993

Published In

Volume / Issue

  • 59 / 2

Start / End Page

  • 339 - 342

PubMed ID

  • 8425628

Pubmed Central ID

  • 8425628

Electronic International Standard Serial Number (EISSN)

  • 1556-5653

International Standard Serial Number (ISSN)

  • 0015-0282

Digital Object Identifier (DOI)

  • 10.1016/s0015-0282(16)55671-4

Language

  • eng