Skip to main content
Journal cover image

Modifying effect of MDM4 variants on risk of HPV16-associated squamous cell carcinoma of oropharynx.

Publication ,  Journal Article
Yu, H; Sturgis, EM; Liu, Z; Wang, L-E; Wei, Q; Li, G
Published in: Cancer
March 15, 2012

BACKGROUND: The p53 pathway plays a critical role in maintaining genomic stability and preventing tumor formation. Given the roles of both MDM4 and HPV16 E6 oncoproteins in inhibition of p53 activity, we tested the hypothesis that MDM4 polymorphisms are associated with the risk of HPV16-associated squamous cell carcinoma of head and neck (SCCHN). METHODS: Genotyping was conducted on 3 tagging single nucleotide polymorphisms (rs11801299 G>A, rs10900598 G>T, and rs1380576 C>G) in MDM4, and serology was used to determine HPV 16 exposure in 380 cases and 335 cancer-free controls that were frequency-matched by age, sex, smoking, and drinking status. RESULTS: None of 3 MDM4 polymorphisms alone was significantly associated with risk of overall SCCHN. With further analysis stratified by HPV16 serology and tumor site, we found that each polymorphism individually modified the risk of HPV16-associated squamous cell carcinoma of the oropharynx (SCCOP), and such effect modification was particularly pronounced in never smokers and never drinkers. CONCLUSION: The risk of HPV16-associated SCCOP could be modified by MDM4 polymorphisms. Large and prospective studies are needed to validate our findings.

Duke Scholars

Published In

Cancer

DOI

EISSN

1097-0142

Publication Date

March 15, 2012

Volume

118

Issue

6

Start / End Page

1684 / 1692

Location

United States

Related Subject Headings

  • Smoking
  • Risk Factors
  • Proto-Oncogene Proteins
  • Polymorphism, Genetic
  • Oropharyngeal Neoplasms
  • Oncology & Carcinogenesis
  • Nuclear Proteins
  • Middle Aged
  • Male
  • Humans
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Yu, H., Sturgis, E. M., Liu, Z., Wang, L.-E., Wei, Q., & Li, G. (2012). Modifying effect of MDM4 variants on risk of HPV16-associated squamous cell carcinoma of oropharynx. Cancer, 118(6), 1684–1692. https://doi.org/10.1002/cncr.26423
Yu, Hongping, Erich M. Sturgis, Zhensheng Liu, Li-E Wang, Qingyi Wei, and Guojun Li. “Modifying effect of MDM4 variants on risk of HPV16-associated squamous cell carcinoma of oropharynx.Cancer 118, no. 6 (March 15, 2012): 1684–92. https://doi.org/10.1002/cncr.26423.
Yu H, Sturgis EM, Liu Z, Wang L-E, Wei Q, Li G. Modifying effect of MDM4 variants on risk of HPV16-associated squamous cell carcinoma of oropharynx. Cancer. 2012 Mar 15;118(6):1684–92.
Yu, Hongping, et al. “Modifying effect of MDM4 variants on risk of HPV16-associated squamous cell carcinoma of oropharynx.Cancer, vol. 118, no. 6, Mar. 2012, pp. 1684–92. Pubmed, doi:10.1002/cncr.26423.
Yu H, Sturgis EM, Liu Z, Wang L-E, Wei Q, Li G. Modifying effect of MDM4 variants on risk of HPV16-associated squamous cell carcinoma of oropharynx. Cancer. 2012 Mar 15;118(6):1684–1692.
Journal cover image

Published In

Cancer

DOI

EISSN

1097-0142

Publication Date

March 15, 2012

Volume

118

Issue

6

Start / End Page

1684 / 1692

Location

United States

Related Subject Headings

  • Smoking
  • Risk Factors
  • Proto-Oncogene Proteins
  • Polymorphism, Genetic
  • Oropharyngeal Neoplasms
  • Oncology & Carcinogenesis
  • Nuclear Proteins
  • Middle Aged
  • Male
  • Humans