Association between a functional polymorphism (-1195T>C) in the IGFBP5 promoter and head and neck cancer risk.


Journal Article

BACKGROUND: To the best of our knowledge, no studies to date have evaluated roles of insulin-like growth factor binding protein 5 (IGFBP5) polymorphisms in risk of squamous cell carcinoma of the head and neck (SCCHN). METHODS: A hospital-based study of 1082 patients with SCCHN and 1120 cancer-free controls was performed to investigate associations between 2 functional polymorphisms, -1195T>C and -709G>C, in the IGFBP5 promoter region and SCCHN risk. RESULTS: We demonstrated that the transcription factor, activator protein 1 (AP-1), differentially bound to T or C variants at -1195 in the promoter to regulate the IGFBP5 promoter activity and that the C variant genotypes were associated with deferential risk of late-stage SCCHN, compared to the TT genotype, particularly for human papillomavirus (HPV)-unrelated sites (adjusted odds ratio [OR], 2.21; 95% confidence interval [CI], 1.19-4.11 for CC vs TT). CONCLUSION: The IGFBP5 -1195T>C polymorphism is functional and may potentially be a biomarker for susceptibility to late-stage SCCHN.

Full Text

Duke Authors

Cited Authors

  • Niu, J; Huang, Y-J; Wei, S; Liu, Z; Wang, L-E; Chang, S; Chamberlain, RM; El-Naggar, AK; Sturgis, EM; Wei, Q

Published Date

  • May 2011

Published In

Volume / Issue

  • 33 / 5

Start / End Page

  • 650 - 660

PubMed ID

  • 20949447

Pubmed Central ID

  • 20949447

Electronic International Standard Serial Number (EISSN)

  • 1097-0347

Digital Object Identifier (DOI)

  • 10.1002/hed.21514


  • eng

Conference Location

  • United States