Functional promoter rs2868371 variant of HSPB1 associates with radiation-induced esophageal toxicity in patients with non-small-cell lung cancer treated with radio(chemo)therapy.

Published

Journal Article

PURPOSE: We investigated the association between single-nucleotide polymorphisms (SNPs) in the heat shock protein beta-1 (HSPB1) gene and the risk of radiation-induced esophageal toxicity (RIET) in patients with non-small-cell lung cancer (NSCLC). MATERIALS AND METHODS: The experimental dataset comprised 120 NSCLC patients who were treated with radio(chemo)therapy between 2005 and 2009, when novel radiation techniques were implemented at MD Anderson. The validation dataset comprised 181 NSCLC patients treated between 1998 and 2004. We genotyped two SNPs of the HSPB1 gene (rs2868370 and rs2868371) by TaqMan assay. RESULTS: Univariate and multivariate analyses of the experimental dataset showed that the CG/GG genotypes of HSPB1 rs2868371 were associated with significantly lower risk of grade ⩾3 RIET than the CC genotype (univariate hazard ratio [HR] 0.30; 95% confidence interval [CI], 0.10-0.91; P=0.033; multivariate HR 0.29; 95% CI, 0.09-0.97; P=0.045). This difference in risk was replicated in the validation cohort despite the different radiation techniques used during that period. CONCLUSIONS: The CG/GG genotypes of HSPB1 rs2868371 were associated with lower risk of RIET, compared with the CC genotype in patients with NSCLC treated with radio(chemo)therapy. This finding should be validated in large multi-institutional prospective trials.

Full Text

Duke Authors

Cited Authors

  • Lopez Guerra, JL; Wei, Q; Yuan, X; Gomez, D; Liu, Z; Zhuang, Y; Yin, M; Li, M; Wang, L-E; Cox, JD; Liao, Z

Published Date

  • November 2011

Published In

Volume / Issue

  • 101 / 2

Start / End Page

  • 271 - 277

PubMed ID

  • 21937138

Pubmed Central ID

  • 21937138

Electronic International Standard Serial Number (EISSN)

  • 1879-0887

Digital Object Identifier (DOI)

  • 10.1016/j.radonc.2011.08.039

Language

  • eng

Conference Location

  • Ireland