Skip to main content
Journal cover image

Genetic polymorphisms of p21 and risk of second primary malignancy in patients with index squamous cell carcinoma of the head and neck.

Publication ,  Journal Article
Lei, D; Sturgis, EM; Liu, Z; Zafereo, ME; Wei, Q; Li, G
Published in: Carcinogenesis
February 2010

p21 plays an important role in modulating cell cycle control, inducing apoptosis, and inhibiting cell growth, subsequently affecting cancer risk. We investigated the association between two putatively functional single-nucleotide polymorphisms (SNPs) of p21 (p21 C98A and p21 C70T) among 1282 patients diagnosed with incident squamous cell carcinoma of the head and neck (SCCHN) and risk of second primary malignancy (SPM) in an ongoing molecular epidemiology study. We used Log-rank test and Cox proportional hazard models to assess the association of these two SNPs with SPM-free survival and SPM risk. We found that patients with either p21 variant genotypes of the two polymorphisms had a significantly reduced SPM-free survival compared with patients with either p21 wild-type homozygous genotypes (Log-rank test, P = 0.0016). Compared with patients having the p21 98 CC and p21 70 CC genotypes, the patients having p21 98 CA/AA and p21 70 CT/TT variant genotypes had a significantly greater risk of developing SPM, respectively, [hazard ratio (HR) = 1.80, 95% CI = 1.14-2.82 for p21 C98A and HR = 1.82, 95% confidence interval (CI) = 1.16-2.85 for p21 C70T]. Moreover, after combining the variant genotypes of two SNPs, patients with variant genotypes had a significantly moderately increased risk for SPM compared with patients with no variant genotypes (HR = 2.00, 95% CI = 1.26-3.00), and the risk was particularly pronounced in several subgroups. Our results support an increased risk of SPM after index SCCHN with both p21 polymorphisms individually and in combination.

Duke Scholars

Published In

Carcinogenesis

DOI

EISSN

1460-2180

Publication Date

February 2010

Volume

31

Issue

2

Start / End Page

222 / 227

Location

England

Related Subject Headings

  • Survival Rate
  • Risk Factors
  • Prognosis
  • Polymorphism, Single Nucleotide
  • Oncology & Carcinogenesis
  • Neoplasms, Second Primary
  • Middle Aged
  • Male
  • Humans
  • Head and Neck Neoplasms
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Lei, D., Sturgis, E. M., Liu, Z., Zafereo, M. E., Wei, Q., & Li, G. (2010). Genetic polymorphisms of p21 and risk of second primary malignancy in patients with index squamous cell carcinoma of the head and neck. Carcinogenesis, 31(2), 222–227. https://doi.org/10.1093/carcin/bgp279
Lei, Dapeng, Erich M. Sturgis, Zhensheng Liu, Mark E. Zafereo, Qingyi Wei, and Guojun Li. “Genetic polymorphisms of p21 and risk of second primary malignancy in patients with index squamous cell carcinoma of the head and neck.Carcinogenesis 31, no. 2 (February 2010): 222–27. https://doi.org/10.1093/carcin/bgp279.
Lei D, Sturgis EM, Liu Z, Zafereo ME, Wei Q, Li G. Genetic polymorphisms of p21 and risk of second primary malignancy in patients with index squamous cell carcinoma of the head and neck. Carcinogenesis. 2010 Feb;31(2):222–7.
Lei, Dapeng, et al. “Genetic polymorphisms of p21 and risk of second primary malignancy in patients with index squamous cell carcinoma of the head and neck.Carcinogenesis, vol. 31, no. 2, Feb. 2010, pp. 222–27. Pubmed, doi:10.1093/carcin/bgp279.
Lei D, Sturgis EM, Liu Z, Zafereo ME, Wei Q, Li G. Genetic polymorphisms of p21 and risk of second primary malignancy in patients with index squamous cell carcinoma of the head and neck. Carcinogenesis. 2010 Feb;31(2):222–227.
Journal cover image

Published In

Carcinogenesis

DOI

EISSN

1460-2180

Publication Date

February 2010

Volume

31

Issue

2

Start / End Page

222 / 227

Location

England

Related Subject Headings

  • Survival Rate
  • Risk Factors
  • Prognosis
  • Polymorphism, Single Nucleotide
  • Oncology & Carcinogenesis
  • Neoplasms, Second Primary
  • Middle Aged
  • Male
  • Humans
  • Head and Neck Neoplasms