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Genetic variants of the vitamin D receptor gene alter risk of cutaneous melanoma.

Publication ,  Journal Article
Li, C; Liu, Z; Zhang, Z; Strom, SS; Gershenwald, JE; Prieto, VG; Lee, JE; Ross, MI; Mansfield, PF; Cormier, JN; Duvic, M; Grimm, EA; Wei, Q
Published in: J Invest Dermatol
February 2007

Sunlight causes DNA damage but also induces production of vitamin D whose metabolite 1,25-(OH)2D3 has antiproliferative and pro-differentiative effects in both melanocytes and cutaneous melanoma (CM) cells mediated through the vitamin D receptor (VDR). We hypothesized that genetic polymorphisms of VDR are associated with risk of CM. In a hospital-based case-control study of 602 non-Hispanic white CM patients and 603 cancer-free control subjects frequency matched by age and sex, we genotyped two VDR polymorphisms (TaqI and FokI) and assessed their association with CM risk. We found that a significantly decreased risk was associated with VDR-TaqI Tt (adjusted odds ratio (OR), 0.70; 95% confidence interval (CI), 0.54-0.90) and Tt+tt (OR=0.70; 95% CI, 0.55-0.89) genotypes, compared with the VDR-TaqI TT genotype, whereas an increased risk was associated with VDR-FokI Ff genotype (OR=1.32; 95% CI, 1.03-1.68), and a borderline significantly increased risk was associated with Ff+ff (OR=1.26; 95% CI, 1.00-1.59) genotypes, compared with the VDR-FokI FF genotype. In conclusion, genetic variants (i.e., TaqI t protective allele and FokI f risk allele) in VDR may alter risk of CM.

Duke Scholars

Published In

J Invest Dermatol

DOI

EISSN

1523-1747

Publication Date

February 2007

Volume

127

Issue

2

Start / End Page

276 / 280

Location

United States

Related Subject Headings

  • White People
  • Skin Neoplasms
  • Receptors, Calcitriol
  • Polymorphism, Genetic
  • Odds Ratio
  • Melanoma
  • Humans
  • Genotype
  • Genetic Variation
  • Genetic Predisposition to Disease
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Li, C., Liu, Z., Zhang, Z., Strom, S. S., Gershenwald, J. E., Prieto, V. G., … Wei, Q. (2007). Genetic variants of the vitamin D receptor gene alter risk of cutaneous melanoma. J Invest Dermatol, 127(2), 276–280. https://doi.org/10.1038/sj.jid.5700544
Li, Chunying, Zhensheng Liu, Zhengdong Zhang, Sara S. Strom, Jeffrey E. Gershenwald, Victor G. Prieto, Jeffrey E. Lee, et al. “Genetic variants of the vitamin D receptor gene alter risk of cutaneous melanoma.J Invest Dermatol 127, no. 2 (February 2007): 276–80. https://doi.org/10.1038/sj.jid.5700544.
Li C, Liu Z, Zhang Z, Strom SS, Gershenwald JE, Prieto VG, et al. Genetic variants of the vitamin D receptor gene alter risk of cutaneous melanoma. J Invest Dermatol. 2007 Feb;127(2):276–80.
Li, Chunying, et al. “Genetic variants of the vitamin D receptor gene alter risk of cutaneous melanoma.J Invest Dermatol, vol. 127, no. 2, Feb. 2007, pp. 276–80. Pubmed, doi:10.1038/sj.jid.5700544.
Li C, Liu Z, Zhang Z, Strom SS, Gershenwald JE, Prieto VG, Lee JE, Ross MI, Mansfield PF, Cormier JN, Duvic M, Grimm EA, Wei Q. Genetic variants of the vitamin D receptor gene alter risk of cutaneous melanoma. J Invest Dermatol. 2007 Feb;127(2):276–280.
Journal cover image

Published In

J Invest Dermatol

DOI

EISSN

1523-1747

Publication Date

February 2007

Volume

127

Issue

2

Start / End Page

276 / 280

Location

United States

Related Subject Headings

  • White People
  • Skin Neoplasms
  • Receptors, Calcitriol
  • Polymorphism, Genetic
  • Odds Ratio
  • Melanoma
  • Humans
  • Genotype
  • Genetic Variation
  • Genetic Predisposition to Disease