Evidence-based therapy prescription in high-cardiovascular risk patients: the REACT study.


Journal Article

BACKGROUND: Data on outpatient care provided to patients at high cardiovascular risk in Brazil are insufficient. OBJECTIVE: To describe the profile and document the clinical practice of outpatient care in patients at high cardiovascular risk in Brazil, regarding the prescription of evidence-based therapies. METHODS: Prospective registry that documented the ambulatory clinical practice in individuals at high cardiovascular risk, which was defined as the presence of the following factors: coronary artery disease, cerebrovascular and peripheral vascular diseases, diabetes, or those with at least three of the following factors: hypertension, smoking, dyslipidemia, age > 70 years, family history of coronary artery disease, chronic kidney disease or asymptomatic carotid artery disease. Basal characteristics were assessed and the rate of prescription of pharmacological and non-pharmacological interventions was analyzed. RESULTS: A total of 2364 consecutive patients were included, of which 52.2% were males, with a mean age of 66.0 years (± 10.1). Of these, 78.3% used antiplatelet agents, 77.0% used statins and of patients with a history of myocardial infarction, 58.0% received beta-blockers. Concomitant use of these three classes of drugs was 34%; 50.9% of hypertensive, 67% of diabetic and 25.7% of dyslipidemic patients did not achieve the goals recommended by guidelines. The main predictors of prescription therapies with proven benefit were centers with a cardiologist and history of coronary artery disease. CONCLUSION: This national and representative registry identified important gaps in the incorporation of therapies with proven benefit, offering a realistic outlook of patients at high cardiovascular risk.

Full Text

Duke Authors

Cited Authors

  • Berwanger, O; Piva e Mattos, LA; Martin, JFV; Lopes, RD; Figueiredo, EL; Magnoni, D; Precoma, DB; Machado, CA; Guimarães, JI; Andrade, JPD

Published Date

  • March 2013

Published In

Volume / Issue

  • 100 / 3

Start / End Page

  • 212 - 220

PubMed ID

  • 23598574

Pubmed Central ID

  • 23598574

Electronic International Standard Serial Number (EISSN)

  • 1678-4170

Digital Object Identifier (DOI)

  • 10.5935/abc.20130062


  • eng por

Conference Location

  • Brazil