Platelet-mediated thrombolysis in patients with δ-storage pool deficiency: a thrombelastographic analysis.

Journal Article

We present the first thrombelastographic descriptions of three patients with δ-storage pool deficiency, a platelet disorder that involves a deficiency of dense granules and moderate bleeding. The patients demonstrated a 49-54% loss of platelet-mediated clot strength over a 1-2-h period after normal thrombus formation. This pattern persisted, with some attenuation of loss of strength following administration of epsilon aminocaproic acid, desmopressin and platelets for tonsillectomy. Assessment of platelet function in patients with platelet granule disorders can be accomplished with thrombelastographic methods in ambulatory and perioperative settings; however, the effects of therapy for this disorder cannot be monitored with thrombelastography without obtaining a blood sample prior to prophylactic hemostatic intervention.

Full Text

Duke Authors

Cited Authors

  • Brodsky, MA; Machovec, KA; Chambers, BP; Nielsen, VG

Published Date

  • October 2011

Published In

Volume / Issue

  • 22 / 7

Start / End Page

  • 610 - 612

PubMed ID

  • 21822127

Electronic International Standard Serial Number (EISSN)

  • 1473-5733

International Standard Serial Number (ISSN)

  • 0957-5235

Digital Object Identifier (DOI)

  • 10.1097/mbc.0b013e328349a2a4

Language

  • eng