Resting state cortical connectivity reflected in EEG coherence in individuals with autism.

Journal Article (Journal Article)

BACKGROUND: Theoretical conceptions of autism spectrum disorder (ASD) and experimental studies of cerebral blood flow suggest abnormalities in connections among distributed neural systems in ASD. METHODS: Functional connectivity was assessed with electroencephalographic coherence between pairs of electrodes in a high-density electrode array in narrow frequency bands among 18 adults with ASD and 18 control adults in an eyes closed resting state. RESULTS: In the theta (3-6 Hz) frequency range, locally elevated coherence was evident for the ASD group, especially within left hemisphere frontal and temporal regions. In the lower alpha range (8-10 Hz), globally reduced coherence was evident for the ASD group within frontal regions and between frontal and all other scalp regions. The ASD group exhibited significantly greater relative power between 3 and 6 Hz and 13-17 Hz and significantly less relative power between 9 and 10 Hz. CONCLUSIONS: Robust patterns of over- and under-connectivity are apparent at distinct spatial and temporal scales in ASD subjects in the eyes closed resting state.

Full Text

Duke Authors

Cited Authors

  • Murias, M; Webb, SJ; Greenson, J; Dawson, G

Published Date

  • August 1, 2007

Published In

Volume / Issue

  • 62 / 3

Start / End Page

  • 270 - 273

PubMed ID

  • 17336944

Pubmed Central ID

  • PMC2001237

International Standard Serial Number (ISSN)

  • 0006-3223

Digital Object Identifier (DOI)

  • 10.1016/j.biopsych.2006.11.012


  • eng

Conference Location

  • United States