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Pericytic-like angiotropism of glioma and melanoma cells.

Publication ,  Journal Article
Lugassy, C; Haroun, RI; Brem, H; Tyler, BM; Jones, RV; Fernandez, PM; Patierno, SR; Kleinman, HK; Barnhill, RL
Published in: Am J Dermatopathol
December 2002

We have identified in malignant melanoma an angiotumoral complex in which tumor cells occupy a pericytic location along the endothelium of microvessels without evidence of intravasation. We have suggested that this pericytic-like angiotropism could be a marker of an extravascular migration of tumor cells along the abluminal surface of vessels. The extravascular migratory metastasis proposed for melanoma has close analogies with glioma migration. To compare our hypothesis of extravascular migration by melanoma with the migration of glioma cells, we have used the B16 murine melanoma cell line and the GL26 murine glioma cell line in an in vivo murine brain tumor model and in vitro using endothelial cells that have formed capillary-like structures and have been cocultivated with tumor cells. In the brain tumors, a clear progression of glioma and melanoma cells was observed along the abluminal surface of vessels, where they occupied a pericytic location along the periendothelial laminin. In vitro, time-lapse videomicroscopy recorded the migration of tumor cells toward endothelial tubules. After 24 hours, both the melanoma cells and the glioma cells were localized along the external surfaces of the vascular tubules, occupying a pericytic-like location. These similarities between glioma and melanoma support the hypothesis of an extravascular migration of melanoma cells, particularly along the abluminal surface of vessels.

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Published In

Am J Dermatopathol

DOI

ISSN

0193-1091

Publication Date

December 2002

Volume

24

Issue

6

Start / End Page

473 / 478

Location

United States

Related Subject Headings

  • Tumor Cells, Cultured
  • Skin Neoplasms
  • Pericytes
  • Neovascularization, Pathologic
  • Neoplasm Metastasis
  • Microscopy, Video
  • Melanoma, Experimental
  • Laminin
  • Glioma
  • Dermatology & Venereal Diseases
 

Citation

APA
Chicago
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MLA
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Lugassy, C., Haroun, R. I., Brem, H., Tyler, B. M., Jones, R. V., Fernandez, P. M., … Barnhill, R. L. (2002). Pericytic-like angiotropism of glioma and melanoma cells. Am J Dermatopathol, 24(6), 473–478. https://doi.org/10.1097/00000372-200212000-00003
Lugassy, Claire, Raymond I. Haroun, Henry Brem, Betty M. Tyler, Robert V. Jones, Patricia M. Fernandez, Steven R. Patierno, Hynda K. Kleinman, and Raymond L. Barnhill. “Pericytic-like angiotropism of glioma and melanoma cells.Am J Dermatopathol 24, no. 6 (December 2002): 473–78. https://doi.org/10.1097/00000372-200212000-00003.
Lugassy C, Haroun RI, Brem H, Tyler BM, Jones RV, Fernandez PM, et al. Pericytic-like angiotropism of glioma and melanoma cells. Am J Dermatopathol. 2002 Dec;24(6):473–8.
Lugassy, Claire, et al. “Pericytic-like angiotropism of glioma and melanoma cells.Am J Dermatopathol, vol. 24, no. 6, Dec. 2002, pp. 473–78. Pubmed, doi:10.1097/00000372-200212000-00003.
Lugassy C, Haroun RI, Brem H, Tyler BM, Jones RV, Fernandez PM, Patierno SR, Kleinman HK, Barnhill RL. Pericytic-like angiotropism of glioma and melanoma cells. Am J Dermatopathol. 2002 Dec;24(6):473–478.

Published In

Am J Dermatopathol

DOI

ISSN

0193-1091

Publication Date

December 2002

Volume

24

Issue

6

Start / End Page

473 / 478

Location

United States

Related Subject Headings

  • Tumor Cells, Cultured
  • Skin Neoplasms
  • Pericytes
  • Neovascularization, Pathologic
  • Neoplasm Metastasis
  • Microscopy, Video
  • Melanoma, Experimental
  • Laminin
  • Glioma
  • Dermatology & Venereal Diseases