Dysregulation of the mTOR pathway secondary to mutations or a hostile microenvironment contributes to cancer and poor wound healing.

Published

Journal Article (Review)

Either heredity mutations or adverse microenvironment conditions may result in dysregulation of the mammalian target of the rapamycin (mTOR) pathway. The former lead to clinical syndromes such as tuberous sclerosis, Peutz-Jeghers syndrome, and Cowden's disease, which are characterized by hamartomatous growth or cancer. The latter can be associated with poor wound healing as described by Goren et al. (2009, this issue).

Full Text

Duke Authors

Cited Authors

  • Clark, RAF; Pavlis, M

Published Date

  • March 2009

Published In

Volume / Issue

  • 129 / 3

Start / End Page

  • 529 - 531

PubMed ID

  • 19209152

Pubmed Central ID

  • 19209152

Electronic International Standard Serial Number (EISSN)

  • 1523-1747

Digital Object Identifier (DOI)

  • 10.1038/jid.2008.441

Language

  • eng

Conference Location

  • United States