Modulation of noradrenergic neuronal firing by selective serotonin reuptake blockers.


Journal Article

Using in vivo extracellular unitary recording, the effect of short term (2-day) and long-term (21-day) administration of the selective 5-HT reuptake inhibitor (SSRI) paroxetine (10 mg kg(-1) day(-1), s.c. using osmotic minipumps) was examined on the spontaneous firing activity of locus coeruleus noradrenergic neurons. Long-term but not short-term treatment significantly decreased firing activity. Thus, it appears that enhancing 5-HT neurotransmission by sustained SSRI administration leads to a reduction of the firing rate of noradrenergic neurons. The SSRI paroxetine therefore alters the activity of noradrenergic neurons with a delay that is consistent with its therapeutic action in depression and panic disorder.

Full Text

Duke Authors

Cited Authors

  • Szabo, ST; de Montigny, C; Blier, P

Published Date

  • February 1999

Published In

Volume / Issue

  • 126 / 3

Start / End Page

  • 568 - 571

PubMed ID

  • 10188964

Pubmed Central ID

  • 10188964

International Standard Serial Number (ISSN)

  • 0007-1188

Digital Object Identifier (DOI)

  • 10.1038/sj.bjp.0702343


  • eng

Conference Location

  • England