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Controlled exposure to diesel exhaust causes increased nitrite in exhaled breath condensate among subjects with asthma.

Publication ,  Journal Article
Hussain, S; Laumbach, R; Coleman, J; Youssef, H; Kelly-McNeil, K; Ohman-Strickland, P; Zhang, J; Kipen, H
Published in: Journal of occupational and environmental medicine
October 2012

To determine whether oxidative/nitrosative stress plays a role in the acute effects of diesel exhaust (DE) on subjects with asthma.In this crossover study, 16 subjects with mild to moderate asthma were exposed to clean filtered air or diluted DE (300 μg/m as PM2.5) for 1 hour with intermittent exercise.Airway hyperreactivity increased 24 hours after exposure to DE compared with clean filtered air (PC20, 14.9 mg/mL vs 19.7 mg/mL; P = 0.012). Nitrite in exhaled breath condensate was elevated immediately after diesel exposure (P = 0.052) and remained elevated 4 and 24 hours after exposure.After exposure to DE, subjects with asthma demonstrated increased airway hyperreactivity and obstruction. Increased nitrite in exhaled breath condensate, in the absence of increased exhaled nitric oxide, suggests a noninflammatory oxidative stress mechanism by which DE affects the lung.

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Published In

Journal of occupational and environmental medicine

DOI

EISSN

1536-5948

ISSN

1076-2752

Publication Date

October 2012

Volume

54

Issue

10

Start / End Page

1186 / 1191

Related Subject Headings

  • Young Adult
  • Vehicle Emissions
  • Oxidative Stress
  • Nitrites
  • Middle Aged
  • Male
  • Humans
  • Female
  • Exercise
  • Environmental & Occupational Health
 

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Hussain, S., Laumbach, R., Coleman, J., Youssef, H., Kelly-McNeil, K., Ohman-Strickland, P., … Kipen, H. (2012). Controlled exposure to diesel exhaust causes increased nitrite in exhaled breath condensate among subjects with asthma. Journal of Occupational and Environmental Medicine, 54(10), 1186–1191. https://doi.org/10.1097/jom.0b013e31826bb64c
Hussain, Sabiha, Robert Laumbach, Jakemia Coleman, Hatim Youssef, Kathie Kelly-McNeil, Pamela Ohman-Strickland, Junfeng Zhang, and Howard Kipen. “Controlled exposure to diesel exhaust causes increased nitrite in exhaled breath condensate among subjects with asthma.Journal of Occupational and Environmental Medicine 54, no. 10 (October 2012): 1186–91. https://doi.org/10.1097/jom.0b013e31826bb64c.
Hussain S, Laumbach R, Coleman J, Youssef H, Kelly-McNeil K, Ohman-Strickland P, et al. Controlled exposure to diesel exhaust causes increased nitrite in exhaled breath condensate among subjects with asthma. Journal of occupational and environmental medicine. 2012 Oct;54(10):1186–91.
Hussain, Sabiha, et al. “Controlled exposure to diesel exhaust causes increased nitrite in exhaled breath condensate among subjects with asthma.Journal of Occupational and Environmental Medicine, vol. 54, no. 10, Oct. 2012, pp. 1186–91. Epmc, doi:10.1097/jom.0b013e31826bb64c.
Hussain S, Laumbach R, Coleman J, Youssef H, Kelly-McNeil K, Ohman-Strickland P, Zhang J, Kipen H. Controlled exposure to diesel exhaust causes increased nitrite in exhaled breath condensate among subjects with asthma. Journal of occupational and environmental medicine. 2012 Oct;54(10):1186–1191.

Published In

Journal of occupational and environmental medicine

DOI

EISSN

1536-5948

ISSN

1076-2752

Publication Date

October 2012

Volume

54

Issue

10

Start / End Page

1186 / 1191

Related Subject Headings

  • Young Adult
  • Vehicle Emissions
  • Oxidative Stress
  • Nitrites
  • Middle Aged
  • Male
  • Humans
  • Female
  • Exercise
  • Environmental & Occupational Health