Acute changes in heart rate variability in subjects with diabetes following a highway traffic exposure.

Journal Article (Journal Article)


To pilot a protocol to evaluate acute cardiovascular effects in in-vehicle exposure to traffic air pollutants in people with diabetes.


Twenty-one volunteers with type 2 diabetes were passengers on 90- to 110-minute car rides on a busy highway. We measured in-vehicle particle number and mass (PM2.5) nitrogen dioxide, and carbon monoxide and heart rate, heart rate variability (HRV), and blood pressure.


Compared with pre-ride measurements, we found a decrease in high frequency (HF) HRV from pre-ride to next day (ratio 0.66, 95% CI = 0.47 to 0.93) and an increase in low frequency to HF ratio at post-ride (ratio 1.92, 95% CI = 1.21 to 3.05) at post-ride. Interquartile range increases in measured pollutants were associated with next-day decreases in HR HRV.


This protocol appears useful for assessing acute adverse cardiovascular effects of in-vehicle exposures among people who have diabetes.

Full Text

Duke Authors

Cited Authors

  • Laumbach, RJ; Rich, DQ; Gandhi, S; Amorosa, L; Schneider, S; Zhang, J; Ohman-Strickland, P; Gong, J; Lelyanov, O; Kipen, HM

Published Date

  • March 2010

Published In

Volume / Issue

  • 52 / 3

Start / End Page

  • 324 - 331

PubMed ID

  • 20190650

Pubmed Central ID

  • PMC4043282

Electronic International Standard Serial Number (EISSN)

  • 1536-5948

International Standard Serial Number (ISSN)

  • 1076-2752

Digital Object Identifier (DOI)

  • 10.1097/jom.0b013e3181d241fa


  • eng