Measurement of inflammation and oxidative stress following drastic changes in air pollution during the Beijing Olympics: a panel study approach.

Journal Article (Review;Journal Article)

Ambient air pollution has been linked to cardiovascular and respiratory morbidity and mortality in epidemiology studies. Frequently, oxidative and nitrosative stress are hypothesized to mediate these pollution effects, however precise mechanisms remain unclear. This paper describes the methodology for a major panel study to examine air pollution effects on these and other mechanistic pathways. The study took place during the drastic air pollution changes accompanying the 2008 Olympics in Beijing, China. After a general description of air pollution health effects, we provide a discussion of panel studies and describe the unique features of this study that make it likely to provide compelling results. This study should lead to a clearer and more precise definition of the role of oxidative and nitrosative stress, as well as other mechanisms, in determining acute morbidity and mortality from air pollution exposure.

Full Text

Duke Authors

Cited Authors

  • Kipen, H; Rich, D; Huang, W; Zhu, T; Wang, G; Hu, M; Lu, S-E; Ohman-Strickland, P; Zhu, P; Wang, Y; Zhang, JJ

Published Date

  • August 2010

Published In

Volume / Issue

  • 1203 /

Start / End Page

  • 160 - 167

PubMed ID

  • 20716299

Pubmed Central ID

  • PMC4049322

Electronic International Standard Serial Number (EISSN)

  • 1749-6632

International Standard Serial Number (ISSN)

  • 0077-8923

Digital Object Identifier (DOI)

  • 10.1111/j.1749-6632.2010.05638.x


  • eng