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1-Hydroxypyrene concentrations in first morning voids and 24-h composite urine: intra- and inter-individual comparisons.

Publication ,  Journal Article
Han, I-K; Duan, X; Zhang, L; Yang, H; Rhoads, GG; Wei, F; Zhang, J
Published in: Journal of exposure science & environmental epidemiology
September 2008

Urinary 1-hydroxypyrene (1-OHP) has been suggested as an exposure biomarker for polycyclic aromatic hydrocarbons (PAHs). However, it remains unknown whether a first morning urine sample can be used to reflect average exposure. In this paper, we examine intra-individual differences and inter-individual associations between first morning voids and 24-h composite urine samples. The analysis was performed using data collected from 100 adults who had a wide range of PAH exposure due to differences in their occupation, e.g., coke oven workers vs. non-coke oven workers. For each subject, all the urine voids within each of two 24-h measurement periods were collected. Results showed a significant (40% to 62%) intra-individual difference between first morning voids and 24-h urinary 1-OHP concentrations (in ng/ml urine). Creatinine adjustments of 1-OHP concentrations (in micromol/mol urinary creatinine) reduced the intra-individual difference by approximately 10%. Across all the subjects, a high overall correlation (r=0.76) was observed between first morning and 24-h average 1-OHP concentrations. Work environment and sampling season were found to significantly affect the relationship between first morning and 24-h 1-OHP concentrations. An increase of 1 ng/ml of first morning urinary 1-OHP predicted an increase of 0.5 and 0.25 ng/ml of 24-h urinary 1-OHP for coke oven workers and non-coke oven workers, respectively. Data collected in a winter season showed a higher correlation between first morning and 24-h concentrations than data collected in a fall season. Creatinine adjustments did not significantly improve overall correlations between first morning void and 24-h measurements, but increased total variances for 24-h urines explained by first morning urines in coke workers.

Duke Scholars

Published In

Journal of exposure science & environmental epidemiology

DOI

EISSN

1559-064X

ISSN

1559-0631

Publication Date

September 2008

Volume

18

Issue

5

Start / End Page

477 / 485

Related Subject Headings

  • Urine
  • Time Factors
  • Seasons
  • Pyrenes
  • Polycyclic Aromatic Hydrocarbons
  • Occupations
  • Occupational Exposure
  • Middle Aged
  • Male
  • Linear Models
 

Citation

APA
Chicago
ICMJE
MLA
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Han, I.-K., Duan, X., Zhang, L., Yang, H., Rhoads, G. G., Wei, F., & Zhang, J. (2008). 1-Hydroxypyrene concentrations in first morning voids and 24-h composite urine: intra- and inter-individual comparisons. Journal of Exposure Science & Environmental Epidemiology, 18(5), 477–485. https://doi.org/10.1038/sj.jes.7500639
Han, In-Kyu, Xiaoli Duan, Lin Zhang, Hongbiao Yang, George G. Rhoads, Fusheng Wei, and Junfeng Zhang. “1-Hydroxypyrene concentrations in first morning voids and 24-h composite urine: intra- and inter-individual comparisons.Journal of Exposure Science & Environmental Epidemiology 18, no. 5 (September 2008): 477–85. https://doi.org/10.1038/sj.jes.7500639.
Han I-K, Duan X, Zhang L, Yang H, Rhoads GG, Wei F, et al. 1-Hydroxypyrene concentrations in first morning voids and 24-h composite urine: intra- and inter-individual comparisons. Journal of exposure science & environmental epidemiology. 2008 Sep;18(5):477–85.
Han, In-Kyu, et al. “1-Hydroxypyrene concentrations in first morning voids and 24-h composite urine: intra- and inter-individual comparisons.Journal of Exposure Science & Environmental Epidemiology, vol. 18, no. 5, Sept. 2008, pp. 477–85. Epmc, doi:10.1038/sj.jes.7500639.
Han I-K, Duan X, Zhang L, Yang H, Rhoads GG, Wei F, Zhang J. 1-Hydroxypyrene concentrations in first morning voids and 24-h composite urine: intra- and inter-individual comparisons. Journal of exposure science & environmental epidemiology. 2008 Sep;18(5):477–485.

Published In

Journal of exposure science & environmental epidemiology

DOI

EISSN

1559-064X

ISSN

1559-0631

Publication Date

September 2008

Volume

18

Issue

5

Start / End Page

477 / 485

Related Subject Headings

  • Urine
  • Time Factors
  • Seasons
  • Pyrenes
  • Polycyclic Aromatic Hydrocarbons
  • Occupations
  • Occupational Exposure
  • Middle Aged
  • Male
  • Linear Models