Lumbar lipomyelomeningocele and sacrococcygeal teratoma in siblings: support for an alternative theory of spinal teratoma formation.

Published

Journal Article

Sacrococcygeal teratomas may arise in association with regional developmental errors affecting the caudal embryonic segments and may originate within lumbosacral lipomas. It is therefore possible that sacrococcygeal teratomas and lumbosacral lipomas represent related disorders of embryogenesis. Accordingly, the authors report the cases of 2 siblings. The first child (female) was born with a mature Altman Type III sacrococcygeal teratoma that was resected when she was a neonate. Subsequently, a younger brother was found soon after birth to have an L-4-level lipomyelomeningocele and underwent partial resection and spinal cord untethering at 4 months of age. Although familial forms of each of these conditions have been reported, this is, to the authors' knowledge, the first reported occurrence of lipomyelomeningocele and sacrococcygeal teratoma in siblings. They propose that an inherited regional tendency to developmental error affecting the caudal embryonic segments was shared by these siblings and resulted in spinal teratoma formation in one of them.

Full Text

Duke Authors

Cited Authors

  • Oliveria, SF; Thompson, EM; Selden, NR

Published Date

  • June 2010

Published In

Volume / Issue

  • 5 / 6

Start / End Page

  • 626 - 629

PubMed ID

  • 20515338

Pubmed Central ID

  • 20515338

Electronic International Standard Serial Number (EISSN)

  • 1933-0715

Digital Object Identifier (DOI)

  • 10.3171/2010.2.PEDS09502

Language

  • eng

Conference Location

  • United States