Immunovirotherapy for the treatment of glioblastoma.
Journal Article (Journal Article)
We have recently described a new murine model of glioblastoma, generated by the implantation of syngeneic glioblastoma stem cells into immunocompetent mice, that recapitulates the salient histopathological and immunological features of the human disease. We employed this model to demonstrate the multifaceted activity of an oncolytic herpes simplex virus genetically modified to express interleukin-12, G47∆-IL12.
Full Text
Duke Authors
Cited Authors
- Cheema, TA; Fecci, PE; Ning, J; Rabkin, SD
Published Date
- January 1, 2014
Published In
Volume / Issue
- 3 / 1
Start / End Page
- e27218 -
PubMed ID
- 24575383
Pubmed Central ID
- PMC3929360
International Standard Serial Number (ISSN)
- 2162-4011
Digital Object Identifier (DOI)
- 10.4161/onci.27218
Language
- eng
Conference Location
- United States