Immunovirotherapy for the treatment of glioblastoma.

Journal Article (Journal Article)

We have recently described a new murine model of glioblastoma, generated by the implantation of syngeneic glioblastoma stem cells into immunocompetent mice, that recapitulates the salient histopathological and immunological features of the human disease. We employed this model to demonstrate the multifaceted activity of an oncolytic herpes simplex virus genetically modified to express interleukin-12, G47∆-IL12.

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Duke Authors

Fecci, Peter Edward

Cited Authors

Cheema, TA; Fecci, PE; Ning, J; Rabkin, SD

Published Date

January 1, 2014

Published In

Oncoimmunology

Volume / Issue

3 / 1

Start / End Page

e27218 -

PubMed ID

24575383

Pubmed Central ID

PMC3929360

International Standard Serial Number (ISSN)

2162-4011

Digital Object Identifier (DOI)

10.4161/onci.27218

Language

Conference Location

United States

Scholars@Duke