Immunovirotherapy for the treatment of glioblastoma.

Journal Article (Journal Article)

We have recently described a new murine model of glioblastoma, generated by the implantation of syngeneic glioblastoma stem cells into immunocompetent mice, that recapitulates the salient histopathological and immunological features of the human disease. We employed this model to demonstrate the multifaceted activity of an oncolytic herpes simplex virus genetically modified to express interleukin-12, G47∆-IL12.

Full Text

Duke Authors

Cited Authors

  • Cheema, TA; Fecci, PE; Ning, J; Rabkin, SD

Published Date

  • January 1, 2014

Published In

Volume / Issue

  • 3 / 1

Start / End Page

  • e27218 -

PubMed ID

  • 24575383

Pubmed Central ID

  • PMC3929360

International Standard Serial Number (ISSN)

  • 2162-4011

Digital Object Identifier (DOI)

  • 10.4161/onci.27218

Language

  • eng

Conference Location

  • United States