Protein-protein docking: overview and performance analysis.

Journal Article (Journal Article)

Protein-protein docking is the computational prediction of protein complex structure given the individually solved component protein structures. It is an important means for understanding the physicochemical forces that underlie macromolecular interactions and a valuable tool for modeling protein complex structures. Here, we report an overview of protein-protein docking with specific emphasis on our Fast Fourier Transform-based rigid-body docking program ZDOCK, which is consistently rated as one of the most accurate docking programs in the Critical Assessment of Predicted Interactions (CAPRI), a series of community-wide blind tests. We also investigate ZDOCK's performance on a non-redundant protein complex benchmark. Finally, we perform regression analysis to better understand the strengths and weaknesses of ZDOCK and to suggest areas of future development for protein-docking algorithms in general.

Full Text

Duke Authors

Cited Authors

  • Wiehe, K; Peterson, MW; Pierce, B; Mintseris, J; Weng, Z

Published Date

  • 2008

Published In

Volume / Issue

  • 413 /

Start / End Page

  • 283 - 314

PubMed ID

  • 18075170

International Standard Serial Number (ISSN)

  • 1064-3745

Digital Object Identifier (DOI)

  • 10.1007/978-1-59745-574-9_11


  • eng

Conference Location

  • United States