Preclinical developments in type 2 diabetes.

Journal Article (Journal Article;Review)

Type 2 diabetes is associated with insulin resistance in peripheral tissues, such as muscle and fat, impaired glucose-stimulated insulin secretion from pancreatic beta-cells and elevated hepatic gluconeogenesis. Current pharmacotherapy does not adequately address the metabolic defects underlying this disease. Thus, novel targets are being explored that enhance insulin action at target tissues, stimulate carbohydrate and fat catabolism, decrease endogenous glucose production and increase pancreatic beta-cell neogenesis and glucose-dependent insulin secretion. This article reviews recent developments in research on several of these targets, namely acetyl-CoA carboxylase 2 (ACC2), I kappa kinase (IKK) beta, dipeptidyl peptidase IV (DPP-IV) and glucagon-like peptide-1 receptor (GLP-1R).

Full Text

Duke Authors

Cited Authors

  • Lenhard, JM; Gottschalk, WK

Published Date

  • November 5, 2002

Published In

Volume / Issue

  • 54 / 9

Start / End Page

  • 1199 - 1212

PubMed ID

  • 12393301

International Standard Serial Number (ISSN)

  • 0169-409X

Digital Object Identifier (DOI)

  • 10.1016/s0169-409x(02)00092-3


  • eng

Conference Location

  • Netherlands