Flow cytometric findings in hemophagocytic lymphohistiocytosis.

Journal Article (Journal Article)

Hemophagocytic lymphohistiocytosis (HLH) is an often fatal hyperinflammatory syndrome. HLH may be inherited, but it more commonly arises secondary to Epstein-Barr virus (EBV) or other infections, hematologic malignancies, or rheumatologic diseases. We identified 17 patients diagnosed with HLH who had flow cytometric analysis of peripheral blood or bone marrow performed at the time of diagnosis. Two patients had primary HLH, and the others had HLH secondary to EBV infection, hematologic malignancies, rheumatologic conditions, or tuberculosis. The marrow typically showed a reactive lymphocytosis and a marked left shift in myelopoiesis regardless of the etiology. Qualitative abnormalities were also found in several cases, including T-cell abnormalities in the majority of the EBV-associated HLH cases. While not specific, flow cytometric findings in HLH are different from the findings in uninvolved marrow samples, and care should be taken not to overinterpret immunophenotypic findings in these cases as indicative of a primary marrow disorder or lymphoma.

Full Text

Duke Authors

Cited Authors

  • McCall, CM; Mudali, S; Arceci, RJ; Small, D; Fuller, S; Gocke, CD; Vuica-Ross, M; Burns, KH; Borowitz, MJ; Duffield, AS

Published Date

  • May 2012

Published In

Volume / Issue

  • 137 / 5

Start / End Page

  • 786 - 794

PubMed ID

  • 22523218

Pubmed Central ID

  • PMC4703085

Electronic International Standard Serial Number (EISSN)

  • 1943-7722

Digital Object Identifier (DOI)

  • 10.1309/AJCPP40MEXWYRLPN


  • eng

Conference Location

  • England