Relation of heart rate with cardiovascular disease in normal-weight individuals: the Chicago Heart Association Detection Project in Industry.

Journal Article (Journal Article)

The authors investigated the association of resting heart rate (RHR) with cardiovascular disease (CVD) risk factors and mortality among normal-weight individuals. Using data from our cohort (baseline examination in 1967-1973), individuals with a body mass index of 18.5 to 24.9 kg/m(2) (men [n=3724] and women [n=4929] aged 18-39; men [n=1959] and women [n=3735] aged 40-59), were grouped by RHR: <75, 75-84, and > or =85 beats per minute (bpm). A lower RHR was associated with lower mean blood pressure (BP) and cigarette use in each subgroup and total cholesterol (TC) and diabetes in men (P<.05). After a 32-year follow-up, hazard ratios (95% confidence intervals) for CVD mortality for an RHR <75 compared with > or =85 bpm adjusted for age, race, education level, BP, cigarette use, diabetes, and TC were 0.58 (0.34-0.84), 0.73(0.56-0.95), and 0.77 (0.61-0.98) for men aged 18 to 39 and men and women aged 40 to 59, respectively. In women aged 18 to 39, the relationship was not significant. In general, normal-weight individuals with lower RHRs have lower levels of CVD risk factors and mortality.

Full Text

Duke Authors

Cited Authors

  • Kizilbash, MA; Daviglus, ML; Dyer, AR; Garside, DB; Hankinson, AL; Yan, LL; Tian, L; Van, L; Wang, R; Greenland, P

Published Date

  • January 2008

Published In

Volume / Issue

  • 11 / 3

Start / End Page

  • 141 - 147

PubMed ID

  • 18607149

Electronic International Standard Serial Number (EISSN)

  • 1751-7141

International Standard Serial Number (ISSN)

  • 1520-037X

Digital Object Identifier (DOI)

  • 10.1111/j.1751-7141.2008.08004.x


  • eng