Porcine carotid arterial material property alterations with induced atheroma: an in vivo study.

Published

Journal Article

OBJECTIVE: A novel methodology has been developed to evaluate regional alterations in arterial wall material properties with induced atheroma in an animal model. METHODS: Atheromatous lesions (fatty, fibro-fatty, and fibrous) were induced in the carotid arteries of a Yucatan miniswine model by endothelial cell denudation and high cholesterol diet. The images at base line and 8 weeks after denudation were obtained using intravascular ultrasound (IVUS) imaging along with hemodynamic data. Finite element analysis (FEA) along with optimization was employed to assess regional alterations in elastic modulus in the presence of atheroma confirmed by histology. RESULTS: In animals with 8 weeks of induced atherosclerosis, the elastic modulus increased-(elastic modulus-all values x 10(4) Pa, mean+/-S.D.) normal elements (9.34+/-0.36) compared to abnormal elements (9.52+/-0.36) (p<0.05 versus normal elements). Wall thickness increased with atheroma formation. These data demonstrate stiffening vascular wall elastic modulus with lesion progression. This is different from the behavior of femoral arteries, where the elastic modulus decreases with early stages of atheroma development followed by an increase as lesions progress. CONCLUSIONS: This methodology permits determination of areas with early atheroma development, follow atheroma progression, and potentially evaluate interventions aimed at decreasing atheroma load and normalizing vascular material properties.

Full Text

Duke Authors

Cited Authors

  • Nagaraj, A; Kim, H; Hamilton, AJ; Mun, J-H; Smulevitz, B; Kane, BJ; Yan, LL; Roth, SI; McPherson, DD; Chandran, KB

Published Date

  • March 2005

Published In

Volume / Issue

  • 27 / 2

Start / End Page

  • 147 - 156

PubMed ID

  • 15642510

Pubmed Central ID

  • 15642510

Electronic International Standard Serial Number (EISSN)

  • 1873-4030

International Standard Serial Number (ISSN)

  • 1350-4533

Digital Object Identifier (DOI)

  • 10.1016/j.medengphy.2004.09.014

Language

  • eng