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Regional material property alterations in porcine femoral arteries with atheroma development.

Publication ,  Journal Article
Hamilton, AJ; Kim, H; Nagaraj, A; Mun, J-H; Yan, LL; Roth, SI; McPherson, DD; Chandran, KB
Published in: Journal of biomechanics
December 2005

We have developed a novel methodology that permits assessment of regional vascular mechanical property alterations in the presence of atheroma in vivo employing a Yucatan miniswine model with induced lesions. Femoral arteries were imaged with intravascular ultrasound. Image data were segmented and, following three-dimensional reconstruction, underwent finite element and sensitivity analysis with optimization to identify regions with altered vascular mechanical properties. All regions were compared to histological analysis. In 12 animals with 8 weeks of endothelial cell denudation and high cholesterol diet (induced atherosclerosis), the elastic modulus initially decreased with early lesion development and then increased with increasing fibrosis-(elastic modulus-all values x10(4)Pa-mean+/-SEM) histologically normal (non-denuded control segment) elements 9.73+/-0.01, fatty elements 9.53+/-0.01, fibrofatty elements 9.41+/-0.03, and fibrous elements 9.68+/-0.02 (all p<0.001 vs. normal elements). Wall thickness, however, increased with atheroma formation. These data demonstrate decreasing vascular material properties with early lesions, followed by an increase as lesions progress. This methodology permits determination of areas with early atheroma development, follow atheroma progression, and potentially evaluate interventions aimed at decreasing atheroma load and normalizing vascular material properties.

Duke Scholars

Published In

Journal of biomechanics

DOI

EISSN

1873-2380

ISSN

0021-9290

Publication Date

December 2005

Volume

38

Issue

12

Start / End Page

2354 / 2364

Related Subject Headings

  • Ultrasonography, Interventional
  • Swine, Miniature
  • Swine
  • Stress, Mechanical
  • Models, Cardiovascular
  • Image Interpretation, Computer-Assisted
  • Femoral Artery
  • Elasticity
  • Computer Simulation
  • Biomedical Engineering
 

Citation

APA
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ICMJE
MLA
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Hamilton, A. J., Kim, H., Nagaraj, A., Mun, J.-H., Yan, L. L., Roth, S. I., … Chandran, K. B. (2005). Regional material property alterations in porcine femoral arteries with atheroma development. Journal of Biomechanics, 38(12), 2354–2364. https://doi.org/10.1016/j.jbiomech.2004.10.018
Hamilton, Andrew J., Hyunggun Kim, Ashwin Nagaraj, Joung-Hwan Mun, Lijing L. Yan, Sanford I. Roth, David D. McPherson, and Krishnan B. Chandran. “Regional material property alterations in porcine femoral arteries with atheroma development.Journal of Biomechanics 38, no. 12 (December 2005): 2354–64. https://doi.org/10.1016/j.jbiomech.2004.10.018.
Hamilton AJ, Kim H, Nagaraj A, Mun J-H, Yan LL, Roth SI, et al. Regional material property alterations in porcine femoral arteries with atheroma development. Journal of biomechanics. 2005 Dec;38(12):2354–64.
Hamilton, Andrew J., et al. “Regional material property alterations in porcine femoral arteries with atheroma development.Journal of Biomechanics, vol. 38, no. 12, Dec. 2005, pp. 2354–64. Epmc, doi:10.1016/j.jbiomech.2004.10.018.
Hamilton AJ, Kim H, Nagaraj A, Mun J-H, Yan LL, Roth SI, McPherson DD, Chandran KB. Regional material property alterations in porcine femoral arteries with atheroma development. Journal of biomechanics. 2005 Dec;38(12):2354–2364.
Journal cover image

Published In

Journal of biomechanics

DOI

EISSN

1873-2380

ISSN

0021-9290

Publication Date

December 2005

Volume

38

Issue

12

Start / End Page

2354 / 2364

Related Subject Headings

  • Ultrasonography, Interventional
  • Swine, Miniature
  • Swine
  • Stress, Mechanical
  • Models, Cardiovascular
  • Image Interpretation, Computer-Assisted
  • Femoral Artery
  • Elasticity
  • Computer Simulation
  • Biomedical Engineering