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Appetite regulatory hormones in women with anorexia nervosa: binge-eating/purging versus restricting type.

Publication ,  Journal Article
Eddy, KT; Lawson, EA; Meade, C; Meenaghan, E; Horton, SE; Misra, M; Klibanski, A; Miller, KK
Published in: The Journal of clinical psychiatry
January 2015

Anorexia nervosa is a psychiatric illness characterized by low weight, disordered eating, and hallmark neuroendocrine dysfunction. Behavioral phenotypes are defined by predominant restriction or bingeing/purging; binge-eating/purging type anorexia nervosa is associated with poorer outcome. The pathophysiology underlying anorexia nervosa types is unknown, but altered hormones, known to be involved in eating behaviors, may play a role.To examine the role of anorexigenic hormones in anorexia nervosa subtypes, we examined serum levels of peptide YY (PYY; total and active [3-36] forms), brain-derived neurotrophic factor (BDNF), and leptin as primary outcomes in women with DSM-5 restricting type anorexia nervosa (n = 50), binge-eating/purging type anorexia nervosa (n = 25), and healthy controls (n = 22). In addition, women completed validated secondary outcome measures of eating disorder psychopathology (Eating Disorder Examination-Questionnaire) and depression and anxiety symptoms (Hamilton Rating Scales for Depression [HDRS] and Anxiety [HARS]). The study samples were collected from May 22, 2004, to February 7, 2012.Mean PYY 3-36 and leptin levels were lower and BDNF levels higher in binge-eating/purging type anorexia nervosa than in restricting type anorexia nervosa (all P values < .05). After controlling for body mass index, differences in PYY and PYY 3-36 between anorexia nervosa types were significant (P < .05) and differences in BDNF were at the trend level (P < .10). PYY 3-36 was positively (r = 0.27, P = .02) and leptin was negatively (r = -0.51, P < .0001) associated with dietary restraint; BDNF was positively associated with frequency of purging (r = 0.21, P = .04); and leptin was negatively associated with frequency of bingeing (r = -0.29, P = .007) and purging (r = -0.31, P = .004).Among women with anorexia nervosa, the anorexigenic hormones PYY, BDNF, and leptin are differentially regulated between the restricting and binge/purge types. Whether these hormone pathways play etiologic roles with regard to anorexia nervosa behavioral types or are compensatory merits further study.

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Published In

The Journal of clinical psychiatry

DOI

EISSN

1555-2101

ISSN

0160-6689

Publication Date

January 2015

Volume

76

Issue

1

Start / End Page

19 / 24

Related Subject Headings

  • Young Adult
  • Psychiatry
  • Peptide YY
  • Leptin
  • Humans
  • Female
  • Comorbidity
  • Brain-Derived Neurotrophic Factor
  • Binge-Eating Disorder
  • Appetite
 

Citation

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Eddy, K. T., Lawson, E. A., Meade, C., Meenaghan, E., Horton, S. E., Misra, M., … Miller, K. K. (2015). Appetite regulatory hormones in women with anorexia nervosa: binge-eating/purging versus restricting type. The Journal of Clinical Psychiatry, 76(1), 19–24. https://doi.org/10.4088/jcp.13m08753
Eddy, Kamryn T., Elizabeth A. Lawson, Christina Meade, Erinne Meenaghan, Sarah E. Horton, Madhusmita Misra, Anne Klibanski, and Karen K. Miller. “Appetite regulatory hormones in women with anorexia nervosa: binge-eating/purging versus restricting type.The Journal of Clinical Psychiatry 76, no. 1 (January 2015): 19–24. https://doi.org/10.4088/jcp.13m08753.
Eddy KT, Lawson EA, Meade C, Meenaghan E, Horton SE, Misra M, et al. Appetite regulatory hormones in women with anorexia nervosa: binge-eating/purging versus restricting type. The Journal of clinical psychiatry. 2015 Jan;76(1):19–24.
Eddy, Kamryn T., et al. “Appetite regulatory hormones in women with anorexia nervosa: binge-eating/purging versus restricting type.The Journal of Clinical Psychiatry, vol. 76, no. 1, Jan. 2015, pp. 19–24. Epmc, doi:10.4088/jcp.13m08753.
Eddy KT, Lawson EA, Meade C, Meenaghan E, Horton SE, Misra M, Klibanski A, Miller KK. Appetite regulatory hormones in women with anorexia nervosa: binge-eating/purging versus restricting type. The Journal of clinical psychiatry. 2015 Jan;76(1):19–24.

Published In

The Journal of clinical psychiatry

DOI

EISSN

1555-2101

ISSN

0160-6689

Publication Date

January 2015

Volume

76

Issue

1

Start / End Page

19 / 24

Related Subject Headings

  • Young Adult
  • Psychiatry
  • Peptide YY
  • Leptin
  • Humans
  • Female
  • Comorbidity
  • Brain-Derived Neurotrophic Factor
  • Binge-Eating Disorder
  • Appetite