Investigation of electrospray ionization and electrostatic focusing devices using a three-dimensional electrospray current density profiler


Journal Article

A novel instrument for profiling the current density of nanoelectrospray ionization plumes in three dimensions has been developed. A hemispherically- shaped electrostatic lens at atmospheric pressure is found to be able to compress the space-charge in nano-ESI and increase the average current density in the plume to three times the nominal value. Ion transmission into a single-quadrupole mass spectrometer is found to roughly double using the electrostatic lens. Data also suggest that ion transmission into the first vacuum region for a skimmer-type mass spectrometer interface using nano-ESI may be typically 40% or better with no special focusing device used. © 2004 American Society for Mass Spectrometry.

Full Text

Duke Authors

Cited Authors

  • Thompson, JW; Eschelbach, JW; Wilburn, RT; Jorgenson, JW

Published Date

  • March 1, 2005

Published In

Volume / Issue

  • 16 / 3

Start / End Page

  • 312 - 323

International Standard Serial Number (ISSN)

  • 1044-0305

Digital Object Identifier (DOI)

  • 10.1016/j.jasms.2004.11.012

Citation Source

  • Scopus