Investigation of electrospray ionization and electrostatic focusing devices using a three-dimensional electrospray current density profiler
Publication
, Journal Article
Thompson, JW; Eschelbach, JW; Wilburn, RT; Jorgenson, JW
Published in: Journal of the American Society for Mass Spectrometry
March 1, 2005
A novel instrument for profiling the current density of nanoelectrospray ionization plumes in three dimensions has been developed. A hemispherically- shaped electrostatic lens at atmospheric pressure is found to be able to compress the space-charge in nano-ESI and increase the average current density in the plume to three times the nominal value. Ion transmission into a single-quadrupole mass spectrometer is found to roughly double using the electrostatic lens. Data also suggest that ion transmission into the first vacuum region for a skimmer-type mass spectrometer interface using nano-ESI may be typically 40% or better with no special focusing device used. © 2004 American Society for Mass Spectrometry.
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Published In
Journal of the American Society for Mass Spectrometry
DOI
ISSN
1044-0305
Publication Date
March 1, 2005
Volume
16
Issue
3
Start / End Page
312 / 323
Related Subject Headings
- Analytical Chemistry
- 3401 Analytical chemistry
- 0306 Physical Chemistry (incl. Structural)
- 0304 Medicinal and Biomolecular Chemistry
- 0301 Analytical Chemistry
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Thompson, J. W., Eschelbach, J. W., Wilburn, R. T., & Jorgenson, J. W. (2005). Investigation of electrospray ionization and electrostatic focusing devices using a three-dimensional electrospray current density profiler. Journal of the American Society for Mass Spectrometry, 16(3), 312–323. https://doi.org/10.1016/j.jasms.2004.11.012
Thompson, J. W., J. W. Eschelbach, R. T. Wilburn, and J. W. Jorgenson. “Investigation of electrospray ionization and electrostatic focusing devices using a three-dimensional electrospray current density profiler.” Journal of the American Society for Mass Spectrometry 16, no. 3 (March 1, 2005): 312–23. https://doi.org/10.1016/j.jasms.2004.11.012.
Thompson JW, Eschelbach JW, Wilburn RT, Jorgenson JW. Investigation of electrospray ionization and electrostatic focusing devices using a three-dimensional electrospray current density profiler. Journal of the American Society for Mass Spectrometry. 2005 Mar 1;16(3):312–23.
Thompson, J. W., et al. “Investigation of electrospray ionization and electrostatic focusing devices using a three-dimensional electrospray current density profiler.” Journal of the American Society for Mass Spectrometry, vol. 16, no. 3, Mar. 2005, pp. 312–23. Scopus, doi:10.1016/j.jasms.2004.11.012.
Thompson JW, Eschelbach JW, Wilburn RT, Jorgenson JW. Investigation of electrospray ionization and electrostatic focusing devices using a three-dimensional electrospray current density profiler. Journal of the American Society for Mass Spectrometry. 2005 Mar 1;16(3):312–323.
Published In
Journal of the American Society for Mass Spectrometry
DOI
ISSN
1044-0305
Publication Date
March 1, 2005
Volume
16
Issue
3
Start / End Page
312 / 323
Related Subject Headings
- Analytical Chemistry
- 3401 Analytical chemistry
- 0306 Physical Chemistry (incl. Structural)
- 0304 Medicinal and Biomolecular Chemistry
- 0301 Analytical Chemistry