Evaluation of SLC11A1 as an inflammatory bowel disease candidate gene.

Published online

Journal Article

BACKGROUND: Significant evidence suggests that a promoter polymorphism within the gene SLC11A1 is involved in susceptibility to both autoimmune and infectious disorders. The aim of this study was to evaluate whether SLC11A1 has a role in the susceptibility to inflammatory bowel disease (IBD) by characterizing a promoter polymorphism within the gene and two short tandem repeat (STR) markers in genetic proximity to SLC11A1. METHODS: The studied population consisted of 484 Caucasians with IBD, 144 population controls, and 348 non-IBD-affected first-degree relatives of IBD patients. IBD subjects were re-categorized at the sub-disease phenotypic level to characterize possible SLC11A1 genotype-phenotype correlations. Polymorphic markers were amplified from germline DNA and typed using gel electrophoresis. Genotype-phenotype correlations were defined using case-control, haplotype, and family-based association studies. RESULTS: This study did not provide compelling evidence for SLC11A1 disease association; most significantly, there was no apparent evidence of SLC11A1 promoter allele association in the studied Crohn's disease population. CONCLUSION: Our results therefore refute previous studies that have shown SLC11A1 promoter polymorphisms are involved in susceptibility to this form of IBD.

Full Text

Duke Authors

Cited Authors

  • Crawford, NPS; Eichenberger, MR; Colliver, DW; Lewis, RK; Cobbs, GA; Petras, RE; Galandiuk, S

Published Date

  • March 9, 2005

Published In

Volume / Issue

  • 6 /

Start / End Page

  • 10 -

PubMed ID

  • 15757519

Pubmed Central ID

  • 15757519

Electronic International Standard Serial Number (EISSN)

  • 1471-2350

Digital Object Identifier (DOI)

  • 10.1186/1471-2350-6-10

Language

  • eng

Conference Location

  • England