Evaluation of SLC11A1 as an inflammatory bowel disease candidate gene.
Journal Article (Journal Article)
BACKGROUND: Significant evidence suggests that a promoter polymorphism within the gene SLC11A1 is involved in susceptibility to both autoimmune and infectious disorders. The aim of this study was to evaluate whether SLC11A1 has a role in the susceptibility to inflammatory bowel disease (IBD) by characterizing a promoter polymorphism within the gene and two short tandem repeat (STR) markers in genetic proximity to SLC11A1. METHODS: The studied population consisted of 484 Caucasians with IBD, 144 population controls, and 348 non-IBD-affected first-degree relatives of IBD patients. IBD subjects were re-categorized at the sub-disease phenotypic level to characterize possible SLC11A1 genotype-phenotype correlations. Polymorphic markers were amplified from germline DNA and typed using gel electrophoresis. Genotype-phenotype correlations were defined using case-control, haplotype, and family-based association studies. RESULTS: This study did not provide compelling evidence for SLC11A1 disease association; most significantly, there was no apparent evidence of SLC11A1 promoter allele association in the studied Crohn's disease population. CONCLUSION: Our results therefore refute previous studies that have shown SLC11A1 promoter polymorphisms are involved in susceptibility to this form of IBD.
Full Text
Duke Authors
Cited Authors
- Crawford, NPS; Eichenberger, MR; Colliver, DW; Lewis, RK; Cobbs, GA; Petras, RE; Galandiuk, S
Published Date
- March 9, 2005
Published In
Volume / Issue
- 6 /
Start / End Page
- 10 -
PubMed ID
- 15757519
Pubmed Central ID
- PMC555593
Electronic International Standard Serial Number (EISSN)
- 1471-2350
Digital Object Identifier (DOI)
- 10.1186/1471-2350-6-10
Language
- eng
Conference Location
- England