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Evaluation of SLC11A1 as an inflammatory bowel disease candidate gene.

Publication ,  Journal Article
Crawford, NPS; Eichenberger, MR; Colliver, DW; Lewis, RK; Cobbs, GA; Petras, RE; Galandiuk, S
Published in: BMC Med Genet
March 9, 2005

BACKGROUND: Significant evidence suggests that a promoter polymorphism within the gene SLC11A1 is involved in susceptibility to both autoimmune and infectious disorders. The aim of this study was to evaluate whether SLC11A1 has a role in the susceptibility to inflammatory bowel disease (IBD) by characterizing a promoter polymorphism within the gene and two short tandem repeat (STR) markers in genetic proximity to SLC11A1. METHODS: The studied population consisted of 484 Caucasians with IBD, 144 population controls, and 348 non-IBD-affected first-degree relatives of IBD patients. IBD subjects were re-categorized at the sub-disease phenotypic level to characterize possible SLC11A1 genotype-phenotype correlations. Polymorphic markers were amplified from germline DNA and typed using gel electrophoresis. Genotype-phenotype correlations were defined using case-control, haplotype, and family-based association studies. RESULTS: This study did not provide compelling evidence for SLC11A1 disease association; most significantly, there was no apparent evidence of SLC11A1 promoter allele association in the studied Crohn's disease population. CONCLUSION: Our results therefore refute previous studies that have shown SLC11A1 promoter polymorphisms are involved in susceptibility to this form of IBD.

Duke Scholars

Published In

BMC Med Genet

DOI

EISSN

1471-2350

Publication Date

March 9, 2005

Volume

6

Start / End Page

10

Location

England

Related Subject Headings

  • Middle Aged
  • Male
  • Inflammatory Bowel Diseases
  • Humans
  • Genotype
  • Genetics & Heredity
  • Genetic Predisposition to Disease
  • Gene Frequency
  • Female
  • Child
 

Citation

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Crawford, N. P. S., Eichenberger, M. R., Colliver, D. W., Lewis, R. K., Cobbs, G. A., Petras, R. E., & Galandiuk, S. (2005). Evaluation of SLC11A1 as an inflammatory bowel disease candidate gene. BMC Med Genet, 6, 10. https://doi.org/10.1186/1471-2350-6-10
Crawford, Nigel P. S., Maurice R. Eichenberger, Daniel W. Colliver, Robert K. Lewis, Gary A. Cobbs, Robert E. Petras, and Susan Galandiuk. “Evaluation of SLC11A1 as an inflammatory bowel disease candidate gene.BMC Med Genet 6 (March 9, 2005): 10. https://doi.org/10.1186/1471-2350-6-10.
Crawford NPS, Eichenberger MR, Colliver DW, Lewis RK, Cobbs GA, Petras RE, et al. Evaluation of SLC11A1 as an inflammatory bowel disease candidate gene. BMC Med Genet. 2005 Mar 9;6:10.
Crawford, Nigel P. S., et al. “Evaluation of SLC11A1 as an inflammatory bowel disease candidate gene.BMC Med Genet, vol. 6, Mar. 2005, p. 10. Pubmed, doi:10.1186/1471-2350-6-10.
Crawford NPS, Eichenberger MR, Colliver DW, Lewis RK, Cobbs GA, Petras RE, Galandiuk S. Evaluation of SLC11A1 as an inflammatory bowel disease candidate gene. BMC Med Genet. 2005 Mar 9;6:10.
Journal cover image

Published In

BMC Med Genet

DOI

EISSN

1471-2350

Publication Date

March 9, 2005

Volume

6

Start / End Page

10

Location

England

Related Subject Headings

  • Middle Aged
  • Male
  • Inflammatory Bowel Diseases
  • Humans
  • Genotype
  • Genetics & Heredity
  • Genetic Predisposition to Disease
  • Gene Frequency
  • Female
  • Child