Increasing incidence of invasive Haemophilus influenzae disease in adults, Utah, USA.

Journal Article

Since the introduction of the Haemophilus influenzae type b vaccine, the incidence of invasive H. influenzae type b disease among children has fallen dramatically, but the effect on invasive H. influenzae disease among adults may be more complex. In this population-based study we examined the epidemiology and outcomes of invasive disease caused by typeable and nontypeable H. influenzae among Utah adults during 1998-2008. The overall incidence increased over the study period from 0.14/100,000 person-years in 1998 to 1.61/100,000 person-years in 2008. The average incidence in persons >65 years old was 2.74/100,000 person-years, accounting for 51% of cases and 67% of deaths. The incidence was highest for nontypeable H. influenzae (0.23/100,000 person-years), followed by H. influenzae type f (0.14/100,000 person-years). The case-fatality rate was 22%. The incidence of invasive H. influenzae in Utah adults appears to be increasing. Invasive H. influenzae infection disproportionately affected the elderly and was associated with a high mortality rate.

Full Text

Duke Authors

Cited Authors

  • Rubach, MP; Bender, JM; Mottice, S; Hanson, K; Weng, HYC; Korgenski, K; Daly, JA; Pavia, AT

Published Date

  • September 2011

Published In

Volume / Issue

  • 17 / 9

Start / End Page

  • 1645 - 1650

PubMed ID

  • 21888789

Electronic International Standard Serial Number (EISSN)

  • 1080-6059

International Standard Serial Number (ISSN)

  • 1080-6040

Digital Object Identifier (DOI)

  • 10.3201/eid1709.101991

Language

  • eng