Long-range charge transport in single G-quadruplex DNA molecules.

Journal Article

DNA and DNA-based polymers are of interest in molecular electronics because of their versatile and programmable structures. However, transport measurements have produced a range of seemingly contradictory results due to differences in the measured molecules and experimental set-ups, and transporting significant current through individual DNA-based molecules remains a considerable challenge. Here, we report reproducible charge transport in guanine-quadruplex (G4) DNA molecules adsorbed on a mica substrate. Currents ranging from tens of picoamperes to more than 100 pA were measured in the G4-DNA over distances ranging from tens of nanometres to more than 100 nm. Our experimental results, combined with theoretical modelling, suggest that transport occurs via a thermally activated long-range hopping between multi-tetrad segments of DNA. These results could re-ignite interest in DNA-based wires and devices, and in the use of such systems in the development of programmable circuits.

Full Text

Duke Authors

Cited Authors

  • Livshits, GI; Stern, A; Rotem, D; Borovok, N; Eidelshtein, G; Migliore, A; Penzo, E; Wind, SJ; Di Felice, R; Skourtis, SS; Cuevas, JC; Gurevich, L; Kotlyar, AB; Porath, D

Published Date

  • December 2014

Published In

Volume / Issue

  • 9 / 12

Start / End Page

  • 1040 - 1046

PubMed ID

  • 25344689

Electronic International Standard Serial Number (EISSN)

  • 1748-3395

International Standard Serial Number (ISSN)

  • 1748-3387

Digital Object Identifier (DOI)

  • 10.1038/nnano.2014.246

Language

  • eng