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Oesophageal and sternohyal muscle fibres are novel Pax3-dependent migratory somite derivatives essential for ingestion.

Publication ,  Journal Article
Minchin, JEN; Williams, VC; Hinits, Y; Low, S; Tandon, P; Fan, C-M; Rawls, JF; Hughes, SM
Published in: Development
July 2013

Striated muscles that enable mouth opening and swallowing during feeding are essential for efficient energy acquisition, and are likely to have played a fundamental role in the success of early jawed vertebrates. The developmental origins and genetic requirements of these muscles are uncertain. Here, we determine by indelible lineage tracing in mouse that fibres of sternohyoid muscle (SHM), which is essential for mouth opening during feeding, and oesophageal striated muscle (OSM), which is crucial for voluntary swallowing, arise from Pax3-expressing somite cells. In vivo Kaede lineage tracing in zebrafish reveals the migratory route of cells from the anteriormost somites to OSM and SHM destinations. Expression of pax3b, a zebrafish duplicate of Pax3, is restricted to the hypaxial region of anterior somites that generate migratory muscle precursors (MMPs), suggesting that Pax3b plays a role in generating OSM and SHM. Indeed, loss of pax3b function led to defective MMP migration and OSM formation, disorganised SHM differentiation, and inefficient ingestion and swallowing of microspheres. Together, our data demonstrate Pax3-expressing somite cells as a source of OSM and SHM fibres, and highlight a conserved role of Pax3 genes in the genesis of these feeding muscles of vertebrates.

Duke Scholars

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Published In

Development

DOI

EISSN

1477-9129

Publication Date

July 2013

Volume

140

Issue

14

Start / End Page

2972 / 2984

Location

England

Related Subject Headings

  • Zebrafish Proteins
  • Zebrafish
  • Somites
  • Paired Box Transcription Factors
  • PAX3 Transcription Factor
  • Myogenic Regulatory Factor 5
  • MyoD Protein
  • Muscle, Striated
  • Muscle Development
  • Mice
 

Citation

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Minchin, J. E. N., Williams, V. C., Hinits, Y., Low, S., Tandon, P., Fan, C.-M., … Hughes, S. M. (2013). Oesophageal and sternohyal muscle fibres are novel Pax3-dependent migratory somite derivatives essential for ingestion. Development, 140(14), 2972–2984. https://doi.org/10.1242/dev.090050
Minchin, James E. N., Victoria C. Williams, Yaniv Hinits, Siewhui Low, Panna Tandon, Chen-Ming Fan, John F. Rawls, and Simon M. Hughes. “Oesophageal and sternohyal muscle fibres are novel Pax3-dependent migratory somite derivatives essential for ingestion.Development 140, no. 14 (July 2013): 2972–84. https://doi.org/10.1242/dev.090050.
Minchin JEN, Williams VC, Hinits Y, Low S, Tandon P, Fan C-M, et al. Oesophageal and sternohyal muscle fibres are novel Pax3-dependent migratory somite derivatives essential for ingestion. Development. 2013 Jul;140(14):2972–84.
Minchin, James E. N., et al. “Oesophageal and sternohyal muscle fibres are novel Pax3-dependent migratory somite derivatives essential for ingestion.Development, vol. 140, no. 14, July 2013, pp. 2972–84. Pubmed, doi:10.1242/dev.090050.
Minchin JEN, Williams VC, Hinits Y, Low S, Tandon P, Fan C-M, Rawls JF, Hughes SM. Oesophageal and sternohyal muscle fibres are novel Pax3-dependent migratory somite derivatives essential for ingestion. Development. 2013 Jul;140(14):2972–2984.
Journal cover image

Published In

Development

DOI

EISSN

1477-9129

Publication Date

July 2013

Volume

140

Issue

14

Start / End Page

2972 / 2984

Location

England

Related Subject Headings

  • Zebrafish Proteins
  • Zebrafish
  • Somites
  • Paired Box Transcription Factors
  • PAX3 Transcription Factor
  • Myogenic Regulatory Factor 5
  • MyoD Protein
  • Muscle, Striated
  • Muscle Development
  • Mice