Increased rectal microbial richness is associated with the presence of colorectal adenomas in humans.

Journal Article (Journal Article)

Differences in the composition of the gut microbial community have been associated with diseases such as obesity, Crohn's disease, ulcerative colitis and colorectal cancer (CRC). We used 454 titanium pyrosequencing of the V1-V2 region of the 16S rRNA gene to characterize adherent bacterial communities in mucosal biopsy samples from 33 subjects with adenomas and 38 subjects without adenomas (controls). Biopsy samples from subjects with adenomas had greater numbers of bacteria from 87 taxa than controls; only 5 taxa were more abundant in control samples. The magnitude of the differences in the distal gut microbiota between patients with adenomas and controls was more pronounced than that of any other clinical parameters including obesity, diet or family history of CRC. This suggests that sequence analysis of the microbiota could be used to identify patients at risk for developing adenomas.

Full Text

Duke Authors

Cited Authors

  • Sanapareddy, N; Legge, RM; Jovov, B; McCoy, A; Burcal, L; Araujo-Perez, F; Randall, TA; Galanko, J; Benson, A; Sandler, RS; Rawls, JF; Abdo, Z; Fodor, AA; Keku, TO

Published Date

  • October 2012

Published In

Volume / Issue

  • 6 / 10

Start / End Page

  • 1858 - 1868

PubMed ID

  • 22622349

Pubmed Central ID

  • PMC3446812

Electronic International Standard Serial Number (EISSN)

  • 1751-7370

Digital Object Identifier (DOI)

  • 10.1038/ismej.2012.43


  • eng

Conference Location

  • England