Reciprocal gut microbiota transplants from zebrafish and mice to germ-free recipients reveal host habitat selection.

Published

Journal Article

The gut microbiotas of zebrafish and mice share six bacterial divisions, although the specific bacteria within these divisions differ. To test how factors specific to host gut habitat shape microbial community structure, we performed reciprocal transplantations of these microbiotas into germ-free zebrafish and mouse recipients. The results reveal that communities are assembled in predictable ways. The transplanted community resembles its community of origin in terms of the lineages present, but the relative abundance of the lineages changes to resemble the normal gut microbial community composition of the recipient host. Thus, differences in community structure between zebrafish and mice arise in part from distinct selective pressures imposed within the gut habitat of each host. Nonetheless, vertebrate responses to microbial colonization of the gut are ancient: Functional genomic studies disclosed shared host responses to their compositionally distinct microbial communities and distinct microbial species that elicit conserved responses.

Full Text

Duke Authors

Cited Authors

  • Rawls, JF; Mahowald, MA; Ley, RE; Gordon, JI

Published Date

  • October 2006

Published In

Volume / Issue

  • 127 / 2

Start / End Page

  • 423 - 433

PubMed ID

  • 17055441

Pubmed Central ID

  • 17055441

Electronic International Standard Serial Number (EISSN)

  • 1097-4172

International Standard Serial Number (ISSN)

  • 0092-8674

Digital Object Identifier (DOI)

  • 10.1016/j.cell.2006.08.043

Language

  • eng