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The broader autism phenotype in simplex and multiplex families.

Publication ,  Journal Article
Gerdts, JA; Bernier, R; Dawson, G; Estes, A
Published in: J Autism Dev Disord
July 2013

Mothers, fathers, and siblings from 87 multiplex (M-mothers, M-fathers, and M-siblings) and 41 simplex (S-mothers, S-fathers, and S-siblings) Autism spectrum disorder families were assessed using the Broader Phenotype Autism Symptom Scale. S-mothers, S-fathers, and S-siblings showed more social interest and were more expressive in their use of nonverbal communication compared to M-mothers, M-fathers, and M-siblings. Conversational skills were also improved in S-fathers and S-siblings compared to M-fathers and M-siblings. S-siblings showed significantly lower rigidity and intense interests compared to M-siblings. The decreased number and intensity of broader autism phenotype traits observed in parents and siblings within simplex families provide behavioral evidence consistent with findings of increased de novo genetic events in simplex families.

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Published In

J Autism Dev Disord

DOI

EISSN

1573-3432

Publication Date

July 2013

Volume

43

Issue

7

Start / End Page

1597 / 1605

Location

United States

Related Subject Headings

  • Social Behavior
  • Phenotype
  • Male
  • Humans
  • Genetic Predisposition to Disease
  • Genetic Carrier Screening
  • Female
  • Developmental & Child Psychology
  • Communication
  • Child, Preschool
 

Citation

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Gerdts, J. A., Bernier, R., Dawson, G., & Estes, A. (2013). The broader autism phenotype in simplex and multiplex families. J Autism Dev Disord, 43(7), 1597–1605. https://doi.org/10.1007/s10803-012-1706-6
Gerdts, Jennifer A., Raphael Bernier, Geraldine Dawson, and Annette Estes. “The broader autism phenotype in simplex and multiplex families.J Autism Dev Disord 43, no. 7 (July 2013): 1597–1605. https://doi.org/10.1007/s10803-012-1706-6.
Gerdts JA, Bernier R, Dawson G, Estes A. The broader autism phenotype in simplex and multiplex families. J Autism Dev Disord. 2013 Jul;43(7):1597–605.
Gerdts, Jennifer A., et al. “The broader autism phenotype in simplex and multiplex families.J Autism Dev Disord, vol. 43, no. 7, July 2013, pp. 1597–605. Pubmed, doi:10.1007/s10803-012-1706-6.
Gerdts JA, Bernier R, Dawson G, Estes A. The broader autism phenotype in simplex and multiplex families. J Autism Dev Disord. 2013 Jul;43(7):1597–1605.
Journal cover image

Published In

J Autism Dev Disord

DOI

EISSN

1573-3432

Publication Date

July 2013

Volume

43

Issue

7

Start / End Page

1597 / 1605

Location

United States

Related Subject Headings

  • Social Behavior
  • Phenotype
  • Male
  • Humans
  • Genetic Predisposition to Disease
  • Genetic Carrier Screening
  • Female
  • Developmental & Child Psychology
  • Communication
  • Child, Preschool