Brief report: biochemical correlates of clinical impairment in high functioning autism and Asperger's disorder.

Journal Article (Journal Article)

Amygdala dysfunction has been proposed as a critical contributor to social impairment in autism spectrum disorders (ASD). The current study investigated biochemical abnormalities in the amygdala in 20 high functioning adults with autistic disorder or Asperger's disorder and 19 typically developing adults matched on age and IQ. Magnetic resonance spectroscopy was used to measure N-acetyl aspartate (NAA), creatine/phosphocreatine (Cre), choline/choline containing compounds (Cho), and Myoinositol (mI) in the right and left amygdala. There were no significant between-group differences in any of the metabolites. However, NAA and Cre levels were significantly correlated to clinical ratings on the Autism Diagnostic Interview-Revised. This suggests that altered metabolite levels in the amygdala may be associated with a more severe early developmental course in ASD.

Full Text

Duke Authors

Cited Authors

  • Kleinhans, NM; Richards, T; Weaver, KE; Liang, O; Dawson, G; Aylward, E

Published Date

  • July 2009

Published In

Volume / Issue

  • 39 / 7

Start / End Page

  • 1079 - 1086

PubMed ID

  • 19234776

Pubmed Central ID

  • PMC4114770

Electronic International Standard Serial Number (EISSN)

  • 1573-3432

Digital Object Identifier (DOI)

  • 10.1007/s10803-009-0707-6


  • eng

Conference Location

  • United States