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Corpus callosum morphometrics in young children with autism spectrum disorder.

Publication ,  Journal Article
Boger-Megiddo, I; Shaw, DWW; Friedman, SD; Sparks, BF; Artru, AA; Giedd, JN; Dawson, G; Dager, SR
Published in: J Autism Dev Disord
August 2006

This study assessed midsagittal corpus callosum cross sectional areas in 3-4 year olds with autism spectrum disorder (ASD) compared to typically developing (TD) and developmentally delayed (DD) children. Though not different in absolute size compared to TD, ASD callosums were disproportionately small adjusted for increased ASD cerebral volume. ASD clinical subgroup analysis revealed greater proportional callosum reduction in the more severely affected autistic disorder (AD) than in pervasive developmental disorder-not otherwise specified (PDD-NOS) children. DD children had smaller absolute callosums than ASD and TD. Subregion analysis revealed widely distributed callosum differences between ASD and TD children. Results could reflect decreased inter-hemispheric connectivity or cerebral enlargement due to increase in tissues less represented in the corpus callosum in ASD.

Duke Scholars

Published In

J Autism Dev Disord

DOI

ISSN

0162-3257

Publication Date

August 2006

Volume

36

Issue

6

Start / End Page

733 / 739

Location

United States

Related Subject Headings

  • Sex Factors
  • Reference Values
  • Mathematical Computing
  • Male
  • Magnetic Resonance Imaging
  • Image Processing, Computer-Assisted
  • Humans
  • Female
  • Diagnosis, Differential
  • Developmental Disabilities
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Boger-Megiddo, I., Shaw, D. W. W., Friedman, S. D., Sparks, B. F., Artru, A. A., Giedd, J. N., … Dager, S. R. (2006). Corpus callosum morphometrics in young children with autism spectrum disorder. J Autism Dev Disord, 36(6), 733–739. https://doi.org/10.1007/s10803-006-0121-2
Boger-Megiddo, Inbal, Dennis W. W. Shaw, Seth D. Friedman, Bobbi F. Sparks, Alan A. Artru, Jay N. Giedd, Geraldine Dawson, and Stephen R. Dager. “Corpus callosum morphometrics in young children with autism spectrum disorder.J Autism Dev Disord 36, no. 6 (August 2006): 733–39. https://doi.org/10.1007/s10803-006-0121-2.
Boger-Megiddo I, Shaw DWW, Friedman SD, Sparks BF, Artru AA, Giedd JN, et al. Corpus callosum morphometrics in young children with autism spectrum disorder. J Autism Dev Disord. 2006 Aug;36(6):733–9.
Boger-Megiddo, Inbal, et al. “Corpus callosum morphometrics in young children with autism spectrum disorder.J Autism Dev Disord, vol. 36, no. 6, Aug. 2006, pp. 733–39. Pubmed, doi:10.1007/s10803-006-0121-2.
Boger-Megiddo I, Shaw DWW, Friedman SD, Sparks BF, Artru AA, Giedd JN, Dawson G, Dager SR. Corpus callosum morphometrics in young children with autism spectrum disorder. J Autism Dev Disord. 2006 Aug;36(6):733–739.
Journal cover image

Published In

J Autism Dev Disord

DOI

ISSN

0162-3257

Publication Date

August 2006

Volume

36

Issue

6

Start / End Page

733 / 739

Location

United States

Related Subject Headings

  • Sex Factors
  • Reference Values
  • Mathematical Computing
  • Male
  • Magnetic Resonance Imaging
  • Image Processing, Computer-Assisted
  • Humans
  • Female
  • Diagnosis, Differential
  • Developmental Disabilities