Familial autoimmune thyroid disease as a risk factor for regression in children with Autism Spectrum Disorder: a CPEA Study.

Journal Article

A multicenter study of 308 children with Autism Spectrum Disorder (ASD) was conducted through the Collaborative Programs of Excellence in Autism (CPEA), sponsored by the National Institute of Child Health and Human Development, to compare the family history of autoimmune disorders in children with ASD with and without a history of regression. A history of regression was determined from the results of the Autism Diagnostic Interview-Revised (ADI-R). Family history of autoimmune disorders was obtained by telephone interview. Regression was significantly associated with a family history of autoimmune disorders (adjusted OR=1.89; 95% CI: 1.17, 3.10). The only specific autoimmune disorder found to be associated with regression was autoimmune thyroid disease (adjusted OR=2.09; 95% CI: 1.28, 3.41).

Full Text

Duke Authors

Cited Authors

  • Molloy, CA; Morrow, AL; Meinzen-Derr, J; Dawson, G; Bernier, R; Dunn, M; Hyman, SL; McMahon, WM; Goudie-Nice, J; Hepburn, S; Minshew, N; Rogers, S; Sigman, M; Spence, MA; Tager-Flusberg, H; Volkmar, FR; Lord, C

Published Date

  • April 2006

Published In

Volume / Issue

  • 36 / 3

Start / End Page

  • 317 - 324

PubMed ID

  • 16598435

Pubmed Central ID

  • 16598435

International Standard Serial Number (ISSN)

  • 0162-3257

Digital Object Identifier (DOI)

  • 10.1007/s10803-005-0071-0


  • eng

Conference Location

  • United States