Alleles of a reelin CGG repeat do not convey liability to autism in a sample from the CPEA network.

Published

Journal Article

A recent study by Persico et al. [2001: Mol Psychiatry 6:150-159] suggests alleles of a CGG polymorphism, just 5' of the reelin gene (RELN) initiator codon, confer liability for autism, especially alleles bearing 11 or more CGG repeats (long alleles). The association is consistent across both a case-control and family-based sample. We attempted to replicate their finding using a larger, independent family-based sample from the NIH Collaborative Programs of Excellence in Autism (CPEA) Network. In our data, allele transmissions to individuals with autism versus unaffected individuals are unbiased, both when alleles are classified by repeat length and when they are classified into long/short categories. Because of the apparent linkage of autism to chromosome 7q, particularly related to the development of language, we also evaluate the relationship between Reelin alleles and the age at which autism subjects use their first word or first phrase. Neither is significantly associated with Reelin alleles. Our results are not consistent with a major role for Reelin alleles in liability to autism.

Full Text

Duke Authors

Cited Authors

  • Devlin, B; Bennett, P; Dawson, G; Figlewicz, DA; Grigorenko, EL; McMahon, W; Minshew, N; Pauls, D; Smith, M; Spence, MA; Rodier, PM; Stodgell, C; Schellenberg, GD; CPEA Genetics Network,

Published Date

  • April 1, 2004

Published In

Volume / Issue

  • 126B / 1

Start / End Page

  • 46 - 50

PubMed ID

  • 15048647

Pubmed Central ID

  • 15048647

International Standard Serial Number (ISSN)

  • 1552-4841

Digital Object Identifier (DOI)

  • 10.1002/ajmg.b.20125

Language

  • eng

Conference Location

  • United States