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Qa-1 restriction of CD8+ suppressor T cells.

Publication ,  Journal Article
Sarantopoulos, S; Lu, L; Cantor, H
Published in: J Clin Invest
November 2004

There is increasing evidence that the immune response can be inhibited by several T cell subsets, including NK T cells, CD25+CD4+ T cells, and a subpopulation of CD8+ T cells. Animal model studies of multiple sclerosis have suggested an important role for suppressor CD8+ T cells in protection against disease recurrence and exacerbation. The molecular lynchpin of CD8+ suppressive activity is the murine MHC molecule Qa-1, termed HLA-E in humans. Here we summarize findings from work on Qa-1 that have begun to delineate suppressor CD8+ T cells and their mechanisms of action in the context of self tolerance and autoimmune disease.

Duke Scholars

Published In

J Clin Invest

DOI

ISSN

0021-9738

Publication Date

November 2004

Volume

114

Issue

9

Start / End Page

1218 / 1221

Location

United States

Related Subject Headings

  • Receptors, Interleukin-2
  • Peptides
  • Models, Biological
  • Mice
  • Immunology
  • Immune Tolerance
  • Humans
  • Histocompatibility Antigens Class I
  • HLA-E Antigens
  • HLA Antigens
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Sarantopoulos, S., Lu, L., & Cantor, H. (2004). Qa-1 restriction of CD8+ suppressor T cells. J Clin Invest, 114(9), 1218–1221. https://doi.org/10.1172/JCI23152
Sarantopoulos, Stefanie, Linrong Lu, and Harvey Cantor. “Qa-1 restriction of CD8+ suppressor T cells.J Clin Invest 114, no. 9 (November 2004): 1218–21. https://doi.org/10.1172/JCI23152.
Sarantopoulos S, Lu L, Cantor H. Qa-1 restriction of CD8+ suppressor T cells. J Clin Invest. 2004 Nov;114(9):1218–21.
Sarantopoulos, Stefanie, et al. “Qa-1 restriction of CD8+ suppressor T cells.J Clin Invest, vol. 114, no. 9, Nov. 2004, pp. 1218–21. Pubmed, doi:10.1172/JCI23152.
Sarantopoulos S, Lu L, Cantor H. Qa-1 restriction of CD8+ suppressor T cells. J Clin Invest. 2004 Nov;114(9):1218–1221.

Published In

J Clin Invest

DOI

ISSN

0021-9738

Publication Date

November 2004

Volume

114

Issue

9

Start / End Page

1218 / 1221

Location

United States

Related Subject Headings

  • Receptors, Interleukin-2
  • Peptides
  • Models, Biological
  • Mice
  • Immunology
  • Immune Tolerance
  • Humans
  • Histocompatibility Antigens Class I
  • HLA-E Antigens
  • HLA Antigens