Qa-1 restriction of CD8+ suppressor T cells.

Journal Article (Journal Article;Review)

There is increasing evidence that the immune response can be inhibited by several T cell subsets, including NK T cells, CD25+CD4+ T cells, and a subpopulation of CD8+ T cells. Animal model studies of multiple sclerosis have suggested an important role for suppressor CD8+ T cells in protection against disease recurrence and exacerbation. The molecular lynchpin of CD8+ suppressive activity is the murine MHC molecule Qa-1, termed HLA-E in humans. Here we summarize findings from work on Qa-1 that have begun to delineate suppressor CD8+ T cells and their mechanisms of action in the context of self tolerance and autoimmune disease.

Full Text

Duke Authors

Cited Authors

  • Sarantopoulos, S; Lu, L; Cantor, H

Published Date

  • November 2004

Published In

Volume / Issue

  • 114 / 9

Start / End Page

  • 1218 - 1221

PubMed ID

  • 15520850

Pubmed Central ID

  • PMC524234

International Standard Serial Number (ISSN)

  • 0021-9738

Digital Object Identifier (DOI)

  • 10.1172/JCI23152


  • eng

Conference Location

  • United States