Influence of embryo sex on development to the blastocyst stage and euploidy.


Journal Article

OBJECTIVE: To compare the prevalence of blastocyst development and euploidy in XX versus XY embryos. DESIGN: Retrospective cohort study. SETTING: Boston IVF, a large university-affiliated reproductive medicine practice. PATIENT(S): All patients who underwent their first preimplantation genetic screening cycle between January 1, 2006, and December 31, 2007. INTERVENTION(S): In vitro fertilization and preimplantation genetic screening. MAIN OUTCOME MEASURE(S): Proportion of embryos that developed to the blastocyst stage by day 5 and prevalence of euploidy for chromosomes 8, 13, 14, 15, 16, 17, 18, 20, 21, and 22 in XX versus XY embryos. RESULT(S): Seven hundred fifty-eight embryos from 138 cycles in 138 patients were analyzed. Three hundred sixty-six (48%) were XX, and 392 (52%) were XY. XX and XY embryos were equally likely to develop to the blastocyst stage by day 5 and were equally likely to be euploid for the analyzed chromosomes. CONCLUSION(S): Our data suggest that extending embryo culture to day 5 does not lead to sex selection and that euploidy and aneuploidy are not sex dependent.

Full Text

Duke Authors

Cited Authors

  • Eaton, JL; Hacker, MR; Barrett, CB; Thornton, KL; Penzias, AS

Published Date

  • March 1, 2011

Published In

Volume / Issue

  • 95 / 3

Start / End Page

  • 936 - 939

PubMed ID

  • 20688326

Pubmed Central ID

  • 20688326

Electronic International Standard Serial Number (EISSN)

  • 1556-5653

Digital Object Identifier (DOI)

  • 10.1016/j.fertnstert.2010.06.063


  • eng

Conference Location

  • United States