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Pri-miR-124 rs531564 and pri-miR-34b/c rs4938723 polymorphisms are associated with decreased risk of esophageal squamous cell carcinoma in Chinese populations.

Publication ,  Journal Article
Zhang, J; Huang, X; Xiao, J; Yang, Y; Zhou, Y; Wang, X; Liu, Q; Yang, J; Wang, M; Qiu, L; Zheng, Y; Zhang, P; Li, J; Wang, Y; Wei, Q ...
Published in: PLoS One
2014

UNLABELLED: MicroRNAs are a new class of small non-protein-coding RNAs that sometimes function as tumor suppressors or oncogenes. Aberrant expression and structural alteration of microRNAs have been reported to be involved in tumorigenesis and cancer development. Recently, rs531564/pri-miR-124-1, rs4938723/pri-miR-34b/c, rs7372209/pri-miR-26a-1, rs895819/pre-miR-27a, and rs11134527/pri-miR-218 were reported to be associated with risks of various cancers. In order to evaluate the relationship of these SNPs and esophageal squamous cell carcinoma (ESCC) risk, we conducted a case-control study with 1109 ESCC patients and 1275 control subjects to examine the potential association of these pri/pre-miRNA polymorphisms with ESCC susceptibility. As a result, two SNPs were associated with a significant risk of ESCC. We found that the GG genotype of pri-miR-124-1 rs531564 was associated to a significantly decreased risk of ESCC comparing with the CC/CG genotypes (p = 0.005; OR = 0.61, 95% CI = 0.43-0.86). In addition, the CC genotype of pri-miR-34b/c rs4938723 was associated with a significant decreased risk of ESCC (CC VS. TT/TC: p = 0.007, OR = 0.82, 95% CI = 0.71-0.95) in Chinese population. The present study provides the first evidence that pri-miR-124-1 rs531564 and pri-miR-34 rs4938723 were associated with the risk of ESCC in Chinese population.

Duke Scholars

Published In

PLoS One

DOI

EISSN

1932-6203

Publication Date

2014

Volume

9

Issue

6

Start / End Page

e100055

Location

United States

Related Subject Headings

  • Smoking
  • Risk Factors
  • Polymorphism, Single Nucleotide
  • Multifactor Dimensionality Reduction
  • Middle Aged
  • MicroRNAs
  • Male
  • Humans
  • Genetic Predisposition to Disease
  • Genetic Association Studies
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Zhang, J., Huang, X., Xiao, J., Yang, Y., Zhou, Y., Wang, X., … Wang, J. (2014). Pri-miR-124 rs531564 and pri-miR-34b/c rs4938723 polymorphisms are associated with decreased risk of esophageal squamous cell carcinoma in Chinese populations. PLoS One, 9(6), e100055. https://doi.org/10.1371/journal.pone.0100055
Zhang, Junjie, Xuewen Huang, Juanjuan Xiao, Yajun Yang, Yinghui Zhou, Xiaofeng Wang, Qingmei Liu, et al. “Pri-miR-124 rs531564 and pri-miR-34b/c rs4938723 polymorphisms are associated with decreased risk of esophageal squamous cell carcinoma in Chinese populations.PLoS One 9, no. 6 (2014): e100055. https://doi.org/10.1371/journal.pone.0100055.
Zhang, Junjie, et al. “Pri-miR-124 rs531564 and pri-miR-34b/c rs4938723 polymorphisms are associated with decreased risk of esophageal squamous cell carcinoma in Chinese populations.PLoS One, vol. 9, no. 6, 2014, p. e100055. Pubmed, doi:10.1371/journal.pone.0100055.
Zhang J, Huang X, Xiao J, Yang Y, Zhou Y, Wang X, Liu Q, Yang J, Wang M, Qiu L, Zheng Y, Zhang P, Li J, Wang Y, Wei Q, Jin L, Wang J. Pri-miR-124 rs531564 and pri-miR-34b/c rs4938723 polymorphisms are associated with decreased risk of esophageal squamous cell carcinoma in Chinese populations. PLoS One. 2014;9(6):e100055.

Published In

PLoS One

DOI

EISSN

1932-6203

Publication Date

2014

Volume

9

Issue

6

Start / End Page

e100055

Location

United States

Related Subject Headings

  • Smoking
  • Risk Factors
  • Polymorphism, Single Nucleotide
  • Multifactor Dimensionality Reduction
  • Middle Aged
  • MicroRNAs
  • Male
  • Humans
  • Genetic Predisposition to Disease
  • Genetic Association Studies