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Association of BRCA1 functional single nucleotide polymorphisms with risk of differentiated thyroid carcinoma.

Publication ,  Journal Article
Xu, L; Doan, PC; Wei, Q; Liu, Y; Li, G; Sturgis, EM
Published in: Thyroid
January 2012

BACKGROUND: Breast cancer 1, early onset (BRCA1) is a vital DNA repair gene, and the single nucleotide polymorphisms (SNPs) of this gene have been studied in diverse cancer types. In this study, we investigated the association between eight common BRCA1 functional SNPs and the risk of differentiated thyroid carcinoma (DTC). METHODS: This cancer center-based case-control study included 303 DTC cases and 511 controls. A polymerase chain reaction-based restriction fragment length polymorphism assay was performed for genotyping. Unconditional logistical regression analysis was used to calculate odds ratios (ORs) and 95% confidence intervals (CIs) in single-SNP analysis and haplotype analysis. RESULTS: A decreased risk of DTC was found for the A1988G heterozygous AG genotype (adjusted OR=0.63, 95% CI: 0.45-0.87, Bonferroni-adjusted p-value=0.036). AATAATA and ATAA haplotypes that carry C33420T variant allele were associated with reduced papillary thyroid cancer risk (adjusted OR=0.52, 95% CI: 0.33-0.84; adjusted OR=0.62, 95% CI: 0.40-0.95, respectively). Also, having a combination of ≥3 favorable genotypes was associated with a DTC risk reduction (adjusted OR=0.69, 95% CI: 0.50-0.95). The A31875G AG/GG genotype was associated with a 69% reduced risk of multifocal primary tumor in DTC patients (adjusted OR=0.31, 95% CI: 0.12-0.81). CONCLUSION: BRCA1 genetic polymorphisms may play a role in DTC risk, while the possible associations warrant confirmation in independent studies.

Duke Scholars

Published In

Thyroid

DOI

EISSN

1557-9077

Publication Date

January 2012

Volume

22

Issue

1

Start / End Page

35 / 43

Location

United States

Related Subject Headings

  • Thyroid Neoplasms
  • Thyroid Cancer, Papillary
  • Polymorphism, Single Nucleotide
  • Middle Aged
  • Male
  • Humans
  • Genotype
  • Genetic Predisposition to Disease
  • Genes, BRCA1
  • Female
 

Citation

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Chicago
ICMJE
MLA
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Xu, L., Doan, P. C., Wei, Q., Liu, Y., Li, G., & Sturgis, E. M. (2012). Association of BRCA1 functional single nucleotide polymorphisms with risk of differentiated thyroid carcinoma. Thyroid, 22(1), 35–43. https://doi.org/10.1089/thy.2011.0117
Xu, Li, Phi C. Doan, Qingyi Wei, Yanhong Liu, Guojun Li, and Erich M. Sturgis. “Association of BRCA1 functional single nucleotide polymorphisms with risk of differentiated thyroid carcinoma.Thyroid 22, no. 1 (January 2012): 35–43. https://doi.org/10.1089/thy.2011.0117.
Xu L, Doan PC, Wei Q, Liu Y, Li G, Sturgis EM. Association of BRCA1 functional single nucleotide polymorphisms with risk of differentiated thyroid carcinoma. Thyroid. 2012 Jan;22(1):35–43.
Xu, Li, et al. “Association of BRCA1 functional single nucleotide polymorphisms with risk of differentiated thyroid carcinoma.Thyroid, vol. 22, no. 1, Jan. 2012, pp. 35–43. Pubmed, doi:10.1089/thy.2011.0117.
Xu L, Doan PC, Wei Q, Liu Y, Li G, Sturgis EM. Association of BRCA1 functional single nucleotide polymorphisms with risk of differentiated thyroid carcinoma. Thyroid. 2012 Jan;22(1):35–43.
Journal cover image

Published In

Thyroid

DOI

EISSN

1557-9077

Publication Date

January 2012

Volume

22

Issue

1

Start / End Page

35 / 43

Location

United States

Related Subject Headings

  • Thyroid Neoplasms
  • Thyroid Cancer, Papillary
  • Polymorphism, Single Nucleotide
  • Middle Aged
  • Male
  • Humans
  • Genotype
  • Genetic Predisposition to Disease
  • Genes, BRCA1
  • Female