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Combined p53-related genetic variants together with HPV infection increase oral cancer risk.

Publication ,  Journal Article
Wang, Z; Sturgis, EM; Zhang, Y; Huang, Z; Zhou, Q; Wei, Q; Li, G
Published in: Int J Cancer
August 1, 2012

To explore the role of polymorphisms of p53-related genes in etiology of oral cancer, we investigated joint effects of seven putatively functional polymorphisms of p53 (codon 72 Arg/Pro), p73 (4/14 GC/AT), murine double minute 2 gene (MDM2; A2164G and T2580G) and MDM4 (rs11801299 G > A, rs10900598 G > T and rs1380576 C > G) on risk of human papillomavirus (HPV)16-associated oral cancer in a case-control study with 325 cases and 335 cancer-free controls. We found that HPV16 seropositivity alone was associated with an increased risk of oral cancer [adjusted odds ratio (OR), 3.1; 95% confidence interval (CI), 2.1-4.6]. After combining genotypes of seven polymorphisms and using the low-risk group (0-3 combined risk genotypes) and HPV16 seronegativity as the reference group, the medium-risk (4 combined risk genotypes) and high-risk groups (5-7 combined risk genotypes) and HPV16 seronegativity were associated with only an OR of 1.6 (95% CI, 1.1-2.5) and 1.2 (95% CI, 0.7-1.9) for oral cancer risk, respectively, whereas the low-risk, medium-risk and high-risk groups and HPV16 seropositivity were significantly associated with a higher OR of 2.1 (95% CI, 1.2-3.6), 4.0 (95% CI, 1.8-9.1) and 19.1 (95% CI, 5.7-64.2), respectively. Notably, such effect modification by these combined risk genotypes was particularly pronounced in young subjects (aged < 50 years), never smokers and patients with oropharyngeal cancer. Taken together, these findings suggest that the combined risk genotypes of p53-related genes may modify risk of HPV16-associated oral cancer, especially in young patients, never-smokers and patients with oropharyngeal cancer. Larger studies are needed to validate our findings.

Duke Scholars

Published In

Int J Cancer

DOI

EISSN

1097-0215

Publication Date

August 1, 2012

Volume

131

Issue

3

Start / End Page

E251 / E258

Location

United States

Related Subject Headings

  • Tumor Suppressor Proteins
  • Tumor Protein p73
  • Risk
  • Proto-Oncogene Proteins c-mdm2
  • Proto-Oncogene Proteins
  • Promoter Regions, Genetic
  • Polymorphism, Single Nucleotide
  • Papillomavirus Infections
  • Oropharyngeal Neoplasms
  • Oncology & Carcinogenesis
 

Citation

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MLA
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Wang, Z., Sturgis, E. M., Zhang, Y., Huang, Z., Zhou, Q., Wei, Q., & Li, G. (2012). Combined p53-related genetic variants together with HPV infection increase oral cancer risk. Int J Cancer, 131(3), E251–E258. https://doi.org/10.1002/ijc.27335
Wang, Zhongqiu, Erich M. Sturgis, Yang Zhang, Zhigang Huang, Qi Zhou, Qingyi Wei, and Guojun Li. “Combined p53-related genetic variants together with HPV infection increase oral cancer risk.Int J Cancer 131, no. 3 (August 1, 2012): E251–58. https://doi.org/10.1002/ijc.27335.
Wang Z, Sturgis EM, Zhang Y, Huang Z, Zhou Q, Wei Q, et al. Combined p53-related genetic variants together with HPV infection increase oral cancer risk. Int J Cancer. 2012 Aug 1;131(3):E251–8.
Wang, Zhongqiu, et al. “Combined p53-related genetic variants together with HPV infection increase oral cancer risk.Int J Cancer, vol. 131, no. 3, Aug. 2012, pp. E251–58. Pubmed, doi:10.1002/ijc.27335.
Wang Z, Sturgis EM, Zhang Y, Huang Z, Zhou Q, Wei Q, Li G. Combined p53-related genetic variants together with HPV infection increase oral cancer risk. Int J Cancer. 2012 Aug 1;131(3):E251–E258.
Journal cover image

Published In

Int J Cancer

DOI

EISSN

1097-0215

Publication Date

August 1, 2012

Volume

131

Issue

3

Start / End Page

E251 / E258

Location

United States

Related Subject Headings

  • Tumor Suppressor Proteins
  • Tumor Protein p73
  • Risk
  • Proto-Oncogene Proteins c-mdm2
  • Proto-Oncogene Proteins
  • Promoter Regions, Genetic
  • Polymorphism, Single Nucleotide
  • Papillomavirus Infections
  • Oropharyngeal Neoplasms
  • Oncology & Carcinogenesis