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Influence of single nucleotide polymorphisms in the MMP1 promoter region on cutaneous melanoma progression.

Publication ,  Journal Article
Liu, H; Wei, Q; Gershenwald, JE; Prieto, VG; Lee, JE; Duvic, M; Grimm, EA; Wang, L-E
Published in: Melanoma Res
April 2012

Recently, we reported on the associations of seven single nucleotide polymorphisms (SNPs) in the promoter region of MMP1 gene with susceptibility to cutaneous melanoma (CM). Considering the reported correlation between MMP1 expression and melanoma progression, we hypothesized that these promoter SNPs might affect CM progression and prognosis. In this study, we examined the associations of seven SNPs with overall survival, as well as six clinicopathological factors in 754 patients with CM. After adjustment for 11 covariates, we observed significant associations of the SNP -422A>T (rs475007) with ulceration status (P=0.012), primary tumor thickness (P=0.040), and anatomic site (P=0.030). We also observed significant associations of the SNP -755T>G (rs498186) with ulceration status (P=0.038) and anatomic site (P=0.003). Two SNPs, -839G>A and -519A>G, were marginally associated with primary tumor thickness, ulceration status, and anatomic site. Furthermore, the frequency of haplotype 2G-G-G-A-A-G-T was higher in patients with ulceration (odds ratio=2.18, 95% confidence interval: 1.08-4.40, P=0.030) compared with those without ulceration. However, we did not find significant associations of these SNPs with overall survival and other clinical factors. As primary tumor thickness and ulceration status are two important indicators of tumor progression and have significant associations with melanoma prognosis, our results suggested that these promoter SNPs in MMP1 might have potential effects on melanoma progression and prognosis by influencing related clinical factors.

Duke Scholars

Published In

Melanoma Res

DOI

EISSN

1473-5636

Publication Date

April 2012

Volume

22

Issue

2

Start / End Page

169 / 175

Location

England

Related Subject Headings

  • Skin Neoplasms
  • Promoter Regions, Genetic
  • Polymorphism, Single Nucleotide
  • Oncology & Carcinogenesis
  • Odds Ratio
  • Middle Aged
  • Melanoma
  • Matrix Metalloproteinase 1
  • Male
  • Linkage Disequilibrium
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Liu, H., Wei, Q., Gershenwald, J. E., Prieto, V. G., Lee, J. E., Duvic, M., … Wang, L.-E. (2012). Influence of single nucleotide polymorphisms in the MMP1 promoter region on cutaneous melanoma progression. Melanoma Res, 22(2), 169–175. https://doi.org/10.1097/CMR.0b013e32834fc46b
Liu, Hongliang, Qingyi Wei, Jeffrey E. Gershenwald, Victor G. Prieto, Jeffrey E. Lee, Madeleine Duvic, Elizabeth A. Grimm, and Li-E Wang. “Influence of single nucleotide polymorphisms in the MMP1 promoter region on cutaneous melanoma progression.Melanoma Res 22, no. 2 (April 2012): 169–75. https://doi.org/10.1097/CMR.0b013e32834fc46b.
Liu H, Wei Q, Gershenwald JE, Prieto VG, Lee JE, Duvic M, et al. Influence of single nucleotide polymorphisms in the MMP1 promoter region on cutaneous melanoma progression. Melanoma Res. 2012 Apr;22(2):169–75.
Liu, Hongliang, et al. “Influence of single nucleotide polymorphisms in the MMP1 promoter region on cutaneous melanoma progression.Melanoma Res, vol. 22, no. 2, Apr. 2012, pp. 169–75. Pubmed, doi:10.1097/CMR.0b013e32834fc46b.
Liu H, Wei Q, Gershenwald JE, Prieto VG, Lee JE, Duvic M, Grimm EA, Wang L-E. Influence of single nucleotide polymorphisms in the MMP1 promoter region on cutaneous melanoma progression. Melanoma Res. 2012 Apr;22(2):169–175.

Published In

Melanoma Res

DOI

EISSN

1473-5636

Publication Date

April 2012

Volume

22

Issue

2

Start / End Page

169 / 175

Location

England

Related Subject Headings

  • Skin Neoplasms
  • Promoter Regions, Genetic
  • Polymorphism, Single Nucleotide
  • Oncology & Carcinogenesis
  • Odds Ratio
  • Middle Aged
  • Melanoma
  • Matrix Metalloproteinase 1
  • Male
  • Linkage Disequilibrium