Neighborhood deprivation and clinical outcomes among head and neck cancer patients.


Journal Article

The unique effects of neighborhood-level economic deprivation on survival, recurrence, and second primary malignancy development were examined using adjusted Cox proportional hazards regression models among 1151 incident squamous cell carcinomas of the head and neck patients. Cancer site was examined as a potential moderator. Main analyses yielded null results; however, interaction analyses indicated poorer overall survival [HR=1.59 (1.00-2.53)] and greater second primary malignancy development [HR=2.99 (1.46-6.11)] among oropharyngeal cancer patients from highly deprived neighborhoods relative to less deprived neighborhoods. Results suggest a dual focus on individual and neighborhood risk factors could help improve clinical outcomes among oropharyngeal cancer patients.

Full Text

Duke Authors

Cited Authors

  • Reitzel, LR; Nguyen, N; Zafereo, ME; Li, G; Wei, Q; Sturgis, EM

Published Date

  • July 2012

Published In

Volume / Issue

  • 18 / 4

Start / End Page

  • 861 - 868

PubMed ID

  • 22445028

Pubmed Central ID

  • 22445028

Electronic International Standard Serial Number (EISSN)

  • 1873-2054

Digital Object Identifier (DOI)

  • 10.1016/j.healthplace.2012.03.005


  • eng

Conference Location

  • England