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p73 G4C14-to-A4T14 gene polymorphism and interaction with p53 exon 4 Arg72Pro on cancer susceptibility: a meta-analysis of the literature.

Publication ,  Journal Article
De Feo, E; Simone, B; Kamgaing, RS; Gallì, P; Hamajima, N; Hu, Z; Li, G; Li, Y; Matsuo, K; Park, JY; Roychoudhury, S; Spitz, MR; Wei, Q ...
Published in: Mutagenesis
May 2012

The p73 gene (1p36-33) is involved in cancer development through cell growth inhibition by inducing apoptosis in a p53-like manner. The p73 G4C14-to-A4T14 dinucleotide polymorphism, consisting of two single-nucleotide polymorphisms in the non-coding region of exon 2 that are in complete linkage disequilibrium, has been extensively studied in association with cancer risk. We performed a meta-analysis of published studies that examined the association between this p73 G4C14-to-A4T14 polymorphism and cancer by searching for relevant studies on Medline and Embase up to February 28, 2010. Pooling data from 19 case-control studies that included 6510 cancer cases and 5711 controls, we found that carriers of the p73 G4C14-to-A4T14 homozygous variant genotype (AT/AT) had an increased global risk of cancer [odds ratio (OR) = 1.30, 95% confidence interval (CI), 1.03-1.65]. There was no evidence of an effect modification of p73 AT/AT by age, gender, ethnicity or smoking status in subgroup analyses; however, a 1.35-fold statistically significant increased risk was found among individuals <55 years old. In case-only analysis, the homozygous p73 G4C14-to-A4T14 variant of p73 genotype was associated with the presence of the p53 exon 4 Arg72Pro allele (OR = 1.30, 95% CI, 1.02-1.64), which is suggestive of a biological interaction between the two genes in carcinogenesis. In conclusion, the p73 G4C14-to-A4T14 homozygous variant genotype might be a risk factor for cancer, especially in combination with the p53 exon 4 Arg72Pro polymorphism. Further studies looking at p73 G4C14-to-A4T14 and p53 exon 4 Arg72Pro interaction are required to support our findings.

Duke Scholars

Published In

Mutagenesis

DOI

EISSN

1464-3804

Publication Date

May 2012

Volume

27

Issue

3

Start / End Page

267 / 273

Location

England

Related Subject Headings

  • Tumor Suppressor Proteins
  • Tumor Suppressor Protein p53
  • Tumor Protein p73
  • Toxicology
  • Risk Factors
  • Polymorphism, Genetic
  • Odds Ratio
  • Nuclear Proteins
  • Neoplasms
  • Humans
 

Citation

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Chicago
ICMJE
MLA
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De Feo, E., Simone, B., Kamgaing, R. S., Gallì, P., Hamajima, N., Hu, Z., … Boccia, S. (2012). p73 G4C14-to-A4T14 gene polymorphism and interaction with p53 exon 4 Arg72Pro on cancer susceptibility: a meta-analysis of the literature. Mutagenesis, 27(3), 267–273. https://doi.org/10.1093/mutage/ger065
De Feo, Emma, Benedetto Simone, Rachel Simo Kamgaing, Paola Gallì, Nobuyuki Hamajima, Zhibin Hu, Guojun Li, et al. “p73 G4C14-to-A4T14 gene polymorphism and interaction with p53 exon 4 Arg72Pro on cancer susceptibility: a meta-analysis of the literature.Mutagenesis 27, no. 3 (May 2012): 267–73. https://doi.org/10.1093/mutage/ger065.
De Feo E, Simone B, Kamgaing RS, Gallì P, Hamajima N, Hu Z, et al. p73 G4C14-to-A4T14 gene polymorphism and interaction with p53 exon 4 Arg72Pro on cancer susceptibility: a meta-analysis of the literature. Mutagenesis. 2012 May;27(3):267–73.
De Feo, Emma, et al. “p73 G4C14-to-A4T14 gene polymorphism and interaction with p53 exon 4 Arg72Pro on cancer susceptibility: a meta-analysis of the literature.Mutagenesis, vol. 27, no. 3, May 2012, pp. 267–73. Pubmed, doi:10.1093/mutage/ger065.
De Feo E, Simone B, Kamgaing RS, Gallì P, Hamajima N, Hu Z, Li G, Li Y, Matsuo K, Park JY, Roychoudhury S, Spitz MR, Wei Q, Zhang J-H, Ricciardi W, Boccia S. p73 G4C14-to-A4T14 gene polymorphism and interaction with p53 exon 4 Arg72Pro on cancer susceptibility: a meta-analysis of the literature. Mutagenesis. 2012 May;27(3):267–273.
Journal cover image

Published In

Mutagenesis

DOI

EISSN

1464-3804

Publication Date

May 2012

Volume

27

Issue

3

Start / End Page

267 / 273

Location

England

Related Subject Headings

  • Tumor Suppressor Proteins
  • Tumor Suppressor Protein p53
  • Tumor Protein p73
  • Toxicology
  • Risk Factors
  • Polymorphism, Genetic
  • Odds Ratio
  • Nuclear Proteins
  • Neoplasms
  • Humans