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Polymorphisms in ERCC1 and XPF genes and risk of gastric cancer in an eastern Chinese population.

Publication ,  Journal Article
He, J; Xu, Y; Qiu, L-X; Li, J; Zhou, X-Y; Sun, M-H; Wang, J-C; Yang, Y-J; Jin, L; Wei, Q-Y; Wang, Y
Published in: PLoS One
2012

BACKGROUND: Inherited functional single nucleotide polymorphisms (SNPs) in DNA repair genes may alter DNA repair capacity and thus contribute to cancer risk. METHODS: Three ERCC1 functional SNPs (rs2298881C>A, rs3212986C>A and rs11615G>A) and two XPF/ERCC4 functional SNPs (rs2276466C>G and rs6498486A>C) were genotyped for 1125 gastric adenocarcinoma cases and 1196 cancer-free controls by Taqman assays. Odds ratios (OR) and 95% confidence intervals (CI) were used to estimate risk associations, and false-positive report probabilities (FPRP) were calculated for assessing significant findings. RESULTS: ERCC1 rs2298881C and rs11615A variant genotypes were associated with increased gastric cancer risk (adjusted OR=1.33, 95% CI=1.05-1.67 for rs2298881 AC/CC and adjusted OR=1.23, 95% CI=1.05-1.46 for rs11615 AG/AA, compared with their common genotype AA and GG, respectively). Patients with 2-3 ERCC1 risk genotypes had significant increased risk (adjusted OR=1.56, 95% CI=1.27-1.93), compared with those with 0-1 ERCC1 risk genotypes, and this risk was more significantly in subgroups of never drinkers, non-gastric cardia adenocarcinoma (NGCA) and clinical stage I+II. All these risks were not observed for XPF SNPs. CONCLUSIONS: These findings suggest that functional ERCC1 SNPs may contribute to risk of gastric cancer. Larger and well-designed studies with different ethnic populations are needed to validate our findings.

Duke Scholars

Published In

PLoS One

DOI

EISSN

1932-6203

Publication Date

2012

Volume

7

Issue

11

Start / End Page

e49308

Location

United States

Related Subject Headings

  • Stomach Neoplasms
  • Risk Factors
  • Polymorphism, Single Nucleotide
  • Odds Ratio
  • Humans
  • Genotype
  • General Science & Technology
  • Endonucleases
  • DNA-Binding Proteins
  • DNA Repair
 

Citation

APA
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He, J., Xu, Y., Qiu, L.-X., Li, J., Zhou, X.-Y., Sun, M.-H., … Wang, Y. (2012). Polymorphisms in ERCC1 and XPF genes and risk of gastric cancer in an eastern Chinese population. PLoS One, 7(11), e49308. https://doi.org/10.1371/journal.pone.0049308
He, Jing, Yu Xu, Li-Xin Qiu, Jin Li, Xiao-Yan Zhou, Meng-Hong Sun, Jiu-Cun Wang, et al. “Polymorphisms in ERCC1 and XPF genes and risk of gastric cancer in an eastern Chinese population.PLoS One 7, no. 11 (2012): e49308. https://doi.org/10.1371/journal.pone.0049308.
He J, Xu Y, Qiu L-X, Li J, Zhou X-Y, Sun M-H, et al. Polymorphisms in ERCC1 and XPF genes and risk of gastric cancer in an eastern Chinese population. PLoS One. 2012;7(11):e49308.
He, Jing, et al. “Polymorphisms in ERCC1 and XPF genes and risk of gastric cancer in an eastern Chinese population.PLoS One, vol. 7, no. 11, 2012, p. e49308. Pubmed, doi:10.1371/journal.pone.0049308.
He J, Xu Y, Qiu L-X, Li J, Zhou X-Y, Sun M-H, Wang J-C, Yang Y-J, Jin L, Wei Q-Y, Wang Y. Polymorphisms in ERCC1 and XPF genes and risk of gastric cancer in an eastern Chinese population. PLoS One. 2012;7(11):e49308.

Published In

PLoS One

DOI

EISSN

1932-6203

Publication Date

2012

Volume

7

Issue

11

Start / End Page

e49308

Location

United States

Related Subject Headings

  • Stomach Neoplasms
  • Risk Factors
  • Polymorphism, Single Nucleotide
  • Odds Ratio
  • Humans
  • Genotype
  • General Science & Technology
  • Endonucleases
  • DNA-Binding Proteins
  • DNA Repair