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Polymorphisms in the XPG gene and risk of gastric cancer in Chinese populations.

Publication ,  Journal Article
He, J; Qiu, L-X; Wang, M-Y; Hua, R-X; Zhang, R-X; Yu, H-P; Wang, Y-N; Sun, M-H; Zhou, X-Y; Yang, Y-J; Wang, J-C; Jin, L; Wei, Q-Y; Li, J
Published in: Hum Genet
July 2012

DNA repair genes play an important role in maintaining stability and integrity of genomic DNA. Polymorphisms in nucleotide excision repair genes may cause variations in DNA repair capacity phenotype and thus contribute to cancer risk. In this case-control study of 1,125 gastric cancer cases and 1,196 cancer-free controls, we investigated the association between three functional single nucleotide polymorphisms (SNPs, rs2296147T > C, rs2094258C > T and rs873601G > A) in the xeroderma pigmentosum group G (XPG) gene and gastric cancer risk. We used the Taqman assays to genotype these three SNPs and logistic regression models to estimate odds ratios (ORs) and 95% confidence intervals (95% CIs). We found that only the rs873601A variant genotypes were associated with a significant higher risk for gastric adenocarcinoma (adjusted OR = 1.30, 95% CI = 1.03-1.64 for AA vs. GG and adjusted OR = 1.23, 95% CI = 1.01-1.49 for AA vs. GG/AG). Stratification analysis indicated that this risk was more pronounced in subgroups of older age (>59 years), males, ever-smokers, and patients with NGCA. All these were not found for the other two SNPs (rs2296147T > C and rs2094258C > T). We then performed expression analysis using gastric cancer adjacent normal tissues from 141 patients and found that the A variant allele was associated with non-significantly reduced expression of XPG mRNA (P(trend) = 0.107). Further analysis using mRNA expression data from the HapMap suggested that the A allele was associated with significantly reduced expression of XPG mRNA in normal cell lines for 45 Chinese (P(trend) = 0.003) as well as for 261 subjects with different ethnicities (P(trend) = 0.001). These support the hypothesis that functional XPG variants may contribute to the risk of gastric cancer. Larger studies with different ethnic populations are warranted to validate our findings.

Duke Scholars

Published In

Hum Genet

DOI

EISSN

1432-1203

Publication Date

July 2012

Volume

131

Issue

7

Start / End Page

1235 / 1244

Location

Germany

Related Subject Headings

  • Young Adult
  • Transcription Factors
  • Stomach Neoplasms
  • RNA, Messenger
  • Polymorphism, Single Nucleotide
  • Nuclear Proteins
  • Middle Aged
  • Male
  • Humans
  • HapMap Project
 

Citation

APA
Chicago
ICMJE
MLA
NLM
He, J., Qiu, L.-X., Wang, M.-Y., Hua, R.-X., Zhang, R.-X., Yu, H.-P., … Li, J. (2012). Polymorphisms in the XPG gene and risk of gastric cancer in Chinese populations. Hum Genet, 131(7), 1235–1244. https://doi.org/10.1007/s00439-012-1152-8
He, Jing, Li-Xin Qiu, Meng-Yun Wang, Rui-Xi Hua, Ruo-Xin Zhang, Hong-Ping Yu, Ya-Nong Wang, et al. “Polymorphisms in the XPG gene and risk of gastric cancer in Chinese populations.Hum Genet 131, no. 7 (July 2012): 1235–44. https://doi.org/10.1007/s00439-012-1152-8.
He J, Qiu L-X, Wang M-Y, Hua R-X, Zhang R-X, Yu H-P, et al. Polymorphisms in the XPG gene and risk of gastric cancer in Chinese populations. Hum Genet. 2012 Jul;131(7):1235–44.
He, Jing, et al. “Polymorphisms in the XPG gene and risk of gastric cancer in Chinese populations.Hum Genet, vol. 131, no. 7, July 2012, pp. 1235–44. Pubmed, doi:10.1007/s00439-012-1152-8.
He J, Qiu L-X, Wang M-Y, Hua R-X, Zhang R-X, Yu H-P, Wang Y-N, Sun M-H, Zhou X-Y, Yang Y-J, Wang J-C, Jin L, Wei Q-Y, Li J. Polymorphisms in the XPG gene and risk of gastric cancer in Chinese populations. Hum Genet. 2012 Jul;131(7):1235–1244.
Journal cover image

Published In

Hum Genet

DOI

EISSN

1432-1203

Publication Date

July 2012

Volume

131

Issue

7

Start / End Page

1235 / 1244

Location

Germany

Related Subject Headings

  • Young Adult
  • Transcription Factors
  • Stomach Neoplasms
  • RNA, Messenger
  • Polymorphism, Single Nucleotide
  • Nuclear Proteins
  • Middle Aged
  • Male
  • Humans
  • HapMap Project