Prognosis significance of HER-2/neu overexpression/amplification in Chinese patients with curatively resected gastric cancer after the ToGA clinical trial.

Published online

Journal Article

BACKGROUND: HER-2/neu-targeted therapy has been successfully used in advanced gastric cancer, but the role of HER-2/neu in the prognosis of gastric cancer is not yet clear. In this study, we investigated the correlation between HER-2/neu expression and amplification as well as their association with clinic outcomes in patients with curatively resected gastric cancer. METHODS: We constructed tissue microarray blocks containing >70% of gastric cancer tissue and matched adjacent normal gastric tissue for 227 patients. Expression of the HER-2/neu protein in these specimens was analyzed using immunohistochemical staining. Amplification of HER-2/neu was also analyzed for the same samples using fluorescence in situ hybridization. Data on clinicopathological features and relevant prognostic factors in these patients were analyzed. RESULTS: Of the 227 gastric cancer samples, 11.89% were positive for HER-2/neu overexpression/amplification under the new scoring system. HER-2/neu overexpression/amplification was closely correlated to the Lauren type, degree of differentiation, tumor size and lymph node metastasis. HER-2/neu overexpression/amplification predicted poor survival in univariate analysis but not in a Cox proportional hazards model. CONCLUSION: HER-2/neu overexpression/amplification was not an independent predictor for survival in patients with curatively resected gastric cancer.

Full Text

Duke Authors

Cited Authors

  • Zhou, F; Li, N; Jiang, W; Hua, Z; Xia, L; Wei, Q; Wang, L

Published Date

  • December 18, 2012

Published In

Volume / Issue

  • 10 /

Start / End Page

  • 274 -

PubMed ID

  • 23249720

Pubmed Central ID

  • 23249720

Electronic International Standard Serial Number (EISSN)

  • 1477-7819

Digital Object Identifier (DOI)

  • 10.1186/1477-7819-10-274

Language

  • eng

Conference Location

  • England