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Single nucleotide polymorphisms of matrix metallopeptidase 3 and risk of gliomas in a Chinese Han population.

Publication ,  Journal Article
Fan, W; Zhou, K; Hu, D; Song, X; Zhao, Y; Chen, H; Wei, Q; Chen, G; Shi, J; Du, G; Mao, Y; Lu, D; Zhou, L
Published in: Mol Carcinog
October 2012

Matrix metallopeptidases (MMPs) play an important role in central nervous system tumor growth, invasion and spreading. The currently available data provide clear evidence for the involvement of MMP3 in the pathophysiology of glioma. The study aims to explore the association of single nucleotide polymorphisms (SNPs) across the MMP3 gene with glioma risk. Three haplotype tagging and additional two promoter SNPs were genotyped among 766 glioma patients and 824 cancer-free controls from East China. None of these polymorphisms alone had a significant effect on risk of gliomas. However, when three promoter polymorphisms were evaluated together by the number of putative risk of genotypes (i.e., rs645419AA, 632478CA+AA, rs522616AA), a statistically significantly increased risk of gliomas was associated with the combined genotypes with two to three risk genotypes, compared with those with zero to one risk genotypes (adjusted odds ratio (OR) = 1.32; 95% confidence interval (CI) = 1.03-1.68). This increased risk was also more pronounced among adults (adjusted OR = 1.14, 95%CI = 1.02-1.27), males (adjusted OR = 1.19, 95%CI = 1.05-1.36), smokers (adjusted OR = 1.28, 95%CI = 1.07-1.52), subjects with no family history of cancer (adjusted OR = 1.21, 95%CI = 1.07-1.37), and patients with nonastrocytic gliomas (adjusted OR = 1.23, 95%CI = 1.06-1.43). In summary, our results suggest that any one of MMP3 variants may not have a substantial effect on glioma risk, but a joint effect of MMP3 promoter polymorphisms may contribute to risk of gliomas, particularly for adult gliomas.

Duke Scholars

Published In

Mol Carcinog

DOI

EISSN

1098-2744

Publication Date

October 2012

Volume

51 Suppl 1

Start / End Page

E1 / 10

Location

United States

Related Subject Headings

  • Risk Factors
  • Promoter Regions, Genetic
  • Polymorphism, Single Nucleotide
  • Oncology & Carcinogenesis
  • Odds Ratio
  • Middle Aged
  • Matrix Metalloproteinase 3
  • Male
  • Humans
  • Haplotypes
 

Citation

APA
Chicago
ICMJE
MLA
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Fan, W., Zhou, K., Hu, D., Song, X., Zhao, Y., Chen, H., … Zhou, L. (2012). Single nucleotide polymorphisms of matrix metallopeptidase 3 and risk of gliomas in a Chinese Han population. Mol Carcinog, 51 Suppl 1, E1-10. https://doi.org/10.1002/mc.20842
Fan, Weiwei, Keke Zhou, Dezhi Hu, Xiao Song, Yingjie Zhao, Hongyan Chen, Qingyi Wei, et al. “Single nucleotide polymorphisms of matrix metallopeptidase 3 and risk of gliomas in a Chinese Han population.Mol Carcinog 51 Suppl 1 (October 2012): E1-10. https://doi.org/10.1002/mc.20842.
Fan W, Zhou K, Hu D, Song X, Zhao Y, Chen H, et al. Single nucleotide polymorphisms of matrix metallopeptidase 3 and risk of gliomas in a Chinese Han population. Mol Carcinog. 2012 Oct;51 Suppl 1:E1-10.
Fan, Weiwei, et al. “Single nucleotide polymorphisms of matrix metallopeptidase 3 and risk of gliomas in a Chinese Han population.Mol Carcinog, vol. 51 Suppl 1, Oct. 2012, pp. E1-10. Pubmed, doi:10.1002/mc.20842.
Fan W, Zhou K, Hu D, Song X, Zhao Y, Chen H, Wei Q, Chen G, Shi J, Du G, Mao Y, Lu D, Zhou L. Single nucleotide polymorphisms of matrix metallopeptidase 3 and risk of gliomas in a Chinese Han population. Mol Carcinog. 2012 Oct;51 Suppl 1:E1-10.
Journal cover image

Published In

Mol Carcinog

DOI

EISSN

1098-2744

Publication Date

October 2012

Volume

51 Suppl 1

Start / End Page

E1 / 10

Location

United States

Related Subject Headings

  • Risk Factors
  • Promoter Regions, Genetic
  • Polymorphism, Single Nucleotide
  • Oncology & Carcinogenesis
  • Odds Ratio
  • Middle Aged
  • Matrix Metalloproteinase 3
  • Male
  • Humans
  • Haplotypes