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A sex-specific association between a 15q25 variant and upper aerodigestive tract cancers.

Publication ,  Journal Article
Chen, D; Truong, T; Gaborieau, V; Byrnes, G; Chabrier, A; Chuang, S-C; Olshan, AF; Weissler, MC; Luo, J; Romkes, M; Buch, S; Nukui, T; Wei, Q ...
Published in: Cancer Epidemiol Biomarkers Prev
April 2011

BACKGROUND: Sequence variants located at 15q25 have been associated with lung cancer and propensity to smoke. We recently reported an association between rs16969968 and risk of upper aerodigestive tract (UADT) cancers (oral cavity, oropharynx, hypopharynx, larynx, and esophagus) in women (OR = 1.24, P = 0.003) with little effect in men (OR = 1.04, P = 0.35). METHODS: In a coordinated genotyping study within the International Head and Neck Cancer Epidemiology (INHANCE) consortium, we have sought to replicate these findings in an additional 4,604 cases and 6,239 controls from 10 independent UADT cancer case-control studies. RESULTS: rs16969968 was again associated with UADT cancers in women (OR = 1.21, 95% CI = 1.08-1.36, P = 0.001) and a similar lack of observed effect in men [OR = 1.02, 95% CI = 0.95-1.09, P = 0.66; P-heterogeneity (P(het)) = 0.01]. In a pooled analysis of the original and current studies, totaling 8,572 UADT cancer cases and 11,558 controls, the association was observed among females (OR = 1.22, 95% CI = 1.12-1.34, P = 7 × 10(-6)) but not males (OR = 1.02, 95% CI = 0.97-1.08, P = 0.35; P(het) = 6 × 10(-4)). There was little evidence for a sex difference in the association between this variant and cigarettes smoked per day, with male and female rs16969968 variant carriers smoking approximately the same amount more in the 11,991 ever smokers in the pooled analysis of the 14 studies (P(het) = 0.86). CONCLUSIONS: This study has confirmed a sex difference in the association between the 15q25 variant rs16969968 and UADT cancers. IMPACT: Further research is warranted to elucidate the mechanisms underlying these observations.

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Published In

Cancer Epidemiol Biomarkers Prev

DOI

EISSN

1538-7755

Publication Date

April 2011

Volume

20

Issue

4

Start / End Page

658 / 664

Location

United States

Related Subject Headings

  • Smoking
  • Sex Factors
  • Middle Aged
  • Male
  • Humans
  • Head and Neck Neoplasms
  • Genotype
  • Female
  • Europe
  • Epidemiology
 

Citation

APA
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MLA
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Chen, D., Truong, T., Gaborieau, V., Byrnes, G., Chabrier, A., Chuang, S.-C., … McKay, J. D. (2011). A sex-specific association between a 15q25 variant and upper aerodigestive tract cancers. Cancer Epidemiol Biomarkers Prev, 20(4), 658–664. https://doi.org/10.1158/1055-9965.EPI-10-1008
Chen, Dan, Therese Truong, Valerie Gaborieau, Graham Byrnes, Amelie Chabrier, Shu-chun Chuang, Andrew F. Olshan, et al. “A sex-specific association between a 15q25 variant and upper aerodigestive tract cancers.Cancer Epidemiol Biomarkers Prev 20, no. 4 (April 2011): 658–64. https://doi.org/10.1158/1055-9965.EPI-10-1008.
Chen D, Truong T, Gaborieau V, Byrnes G, Chabrier A, Chuang S-C, et al. A sex-specific association between a 15q25 variant and upper aerodigestive tract cancers. Cancer Epidemiol Biomarkers Prev. 2011 Apr;20(4):658–64.
Chen, Dan, et al. “A sex-specific association between a 15q25 variant and upper aerodigestive tract cancers.Cancer Epidemiol Biomarkers Prev, vol. 20, no. 4, Apr. 2011, pp. 658–64. Pubmed, doi:10.1158/1055-9965.EPI-10-1008.
Chen D, Truong T, Gaborieau V, Byrnes G, Chabrier A, Chuang S-C, Olshan AF, Weissler MC, Luo J, Romkes M, Buch S, Nukui T, Franceschi S, Herrero R, Talamini R, Kelsey KT, Christensen B, McClean MD, Lacko M, Manni JJ, Peters WHM, Lubiński J, Trubicka J, Lener M, Muscat JE, Lazarus P, Wei Q, Sturgis EM, Zhang Z-F, Chang S-C, Wang R, Schwartz SM, Chen C, Benhamou S, Lagiou P, Holcátová I, Richiardi L, Kjaerheim K, Agudo A, Castellsagué X, Macfarlane TV, Barzan L, Canova C, Thakker NS, Conway DI, Znaor A, Healy CM, Ahrens W, Zaridze D, Szeszenia-Dabrowska N, Lissowska J, Fabianova E, Bucur A, Bencko V, Foretova L, Janout V, Curado MP, Koifman S, Menezes A, Wünsch-Filho V, Eluf-Neto J, Fernandez L, Boccia S, Hashibe M, Hayes RB, Boffetta P, Brennan P, McKay JD. A sex-specific association between a 15q25 variant and upper aerodigestive tract cancers. Cancer Epidemiol Biomarkers Prev. 2011 Apr;20(4):658–664.

Published In

Cancer Epidemiol Biomarkers Prev

DOI

EISSN

1538-7755

Publication Date

April 2011

Volume

20

Issue

4

Start / End Page

658 / 664

Location

United States

Related Subject Headings

  • Smoking
  • Sex Factors
  • Middle Aged
  • Male
  • Humans
  • Head and Neck Neoplasms
  • Genotype
  • Female
  • Europe
  • Epidemiology